CAS 130209-90-4

(±)-Clopidogrel hydrochloride

Description:

(±)-Clopidogrel hydrochloride is a thienopyridine derivative primarily used as an antiplatelet medication to prevent blood clots in patients with cardiovascular diseases. It functions as a prodrug, requiring metabolic activation to exert its therapeutic effects by irreversibly inhibiting the P2Y12 receptor on platelets, thereby reducing platelet aggregation. The substance appears as a white to off-white crystalline powder and is soluble in water and methanol, with limited solubility in organic solvents. Its molecular formula reflects a complex structure that includes a thiophene ring, contributing to its pharmacological activity. The hydrochloride salt form enhances its stability and solubility, facilitating oral administration. Clopidogrel is often prescribed in conjunction with aspirin for dual antiplatelet therapy, particularly after stent placement or in patients with acute coronary syndromes. Side effects may include bleeding complications, gastrointestinal disturbances, and, in rare cases, hypersensitivity reactions. Monitoring is essential to ensure efficacy and safety, especially in patients with specific genetic polymorphisms affecting drug metabolism.

Formula: C₁₆H₁₆ClNO₂S·ClH

InChI: InChI=1S/C16H16ClNO2S.ClH/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;/h2-5,7,9,15H,6,8,10H2,1H3;1H

InChI key: InChIKey=XIHVAFJSGWDBGA-UHFFFAOYSA-N

SMILES: C(C(OC)=O)(N1CC2=C(CC1)SC=C2)C3=C(Cl)C=CC=C3.Cl

Synonyms:

• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, methyl ester, hydrochloride
• PCR 4099
• Methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate hydrochloride
• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, methyl ester, hydrochloride, (±)-
• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, methyl ester, hydrochloride (1:1)

(R,S)-Methyl-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothino[3.2-c]pyridin-5-yl)acetatehydrochloride

CAS: 130209-90-4

Formula: C₁₆H₁₇Cl₂NO₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 358.2827

Ref: IN-DA00A7RT

Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate hydrochloride

CAS: 130209-90-4

Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate hydrochloride

Purity: 98%

Molecular weight: 358.29g/mol

Ref: 54-OR1063179

(±)-Clopidogrel (hydrochloride)

CAS: 130209-90-4

Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM

Formula: C₁₆H₁₇Cl₂NO₂S

Color and Shape: Solid

Molecular weight: 358.28

Ref: TM-T35431

(±)-Clopidogrel hydrochloride

CAS: 130209-90-4

Clopidogrel is a prodrug that must be activated by the enzyme CYP2C19 to become its active form, clopidogrel. It is a platelet inhibitor used as an anti-platelet agent and diagnostic tool. Clopidogrel inhibits the action of adenosine diphosphate (ADP) on the P2Y12 receptor and is also a potent pump inhibitor. The major route of metabolism of clopidogrel is through CYP2C19, although other routes such as enteric are present. Inhibitors of this enzyme can affect clopidogrel's effectiveness. Clopidogrel has been shown to be effective in preventing cancer and tumours in rodents, but not humans. It has been found to inhibit cell proliferation in human epithelial cancers when applied orally or topically.

Formula: C₁₆H₁₇Cl₂NO₂S

Purity: Min. 95%

Molecular weight: 358.3 g/mol

Ref: 3D-FFA20990

(±)-Clopidogrel hydrochloride

CAS: 130209-90-4

Formula: C₁₆H₁₆ClNO₂SHCl

Molecular weight: 321.82 : 36.46

Ref: ST-EA-CP-C2111