CAS 130306-02-4

Tezacitabine

Description:

Tezacitabine, with the CAS number 130306-02-4, is a synthetic nucleoside analog that belongs to the class of antiviral and anticancer agents. It is structurally related to cytidine and is characterized by the presence of a 2'-deoxy-2'-fluoro modification, which enhances its stability and efficacy against certain viral and cancerous cells. Tezacitabine functions primarily as an inhibitor of DNA synthesis, disrupting the replication process in rapidly dividing cells, which makes it a candidate for treating various malignancies, particularly hematological cancers. Its mechanism of action involves incorporation into the DNA strand, leading to chain termination during replication. The compound has been studied for its potential in combination therapies, enhancing the effectiveness of other chemotherapeutic agents. While it has shown promise in clinical trials, its use is subject to ongoing research to better understand its pharmacokinetics, optimal dosing regimens, and potential side effects. Overall, Tezacitabine represents a significant advancement in the development of targeted cancer therapies.

Formula: C₁₀H₁₂FN₃O₄

InChI: InChI=1S/C10H12FN3O4/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17/h1-3,6,8-9,15-16H,4H2,(H2,12,13,17)/b5-3+/t6-,8+,9-/m1/s1

InChI key: InChIKey=GFFXZLZWLOBBLO-ASKVSEFXSA-N

SMILES: C(\F)=C\1/[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)C=C2

Synonyms:

• (2′E)-2′-Deoxy-2′-(fluoromethylene)cytidine
• Cytidine, 2′-deoxy-2′-(fluoromethylene)-, (2′E)-
• Kw 2331
• Mdl 101731
• Tezaciabine
• Tezacitabine
• (E)-2′-Deoxy-2′-(fluoromethylene)cytidine
• FMdC

(E)-2''-Deoxy-2''-(fluoromethylene)cytidine

CAS: 130306-02-4

Ref: 7W-GN7196

(E)-2'-Deoxy-2'-(fluoromethylene)cytidine

CAS: 130306-02-4

(E)-2'-Deoxy-2'-(fluoromethylene)cytidine is a cytostatic compound that inhibits DNA synthesis in tumor cells. It has been shown to be more potent than tezacitabine and hl-60 cells, as well as being less toxic than benzimidazole compounds. This analog of cytosine has been shown to have potent antitumor activity against carcinoma cell lines and myeloid leukemia cell lines. The oral prodrug form of this drug has been shown to be an effective treatment for myeloid leukemia in mice.

Formula: C₁₀H₁₂FN₃O₄

Purity: Min. 95%

Molecular weight: 257.22 g/mol

Ref: 3D-ND10202

Tezacitabine

Controlled Product

CAS: 130306-02-4

Formula: C₁₀H₁₂FN₃O₄

Color and Shape: Neat

Molecular weight: 257.218

Ref: TR-T321540

Tezacitabine

CAS: 130306-02-4

Tezacitabine, a nucleoside analogue, inhibits ribonucleotide reductase, disrupts DNA replication, and induces apoptosis in tumor cells.

Formula: C₁₀H₁₂FN₃O₄

Color and Shape: Solid

Molecular weight: 257.22

Ref: TM-T60401