CAS 130308-48-4: Icatibant

Description: Icatibant is a synthetic peptide and a selective bradykinin B2 receptor antagonist, primarily used in the treatment of hereditary angioedema, a condition characterized by recurrent episodes of severe swelling. Its mechanism of action involves blocking the effects of bradykinin, a peptide that promotes vasodilation and increases vascular permeability, thereby alleviating the symptoms associated with angioedema. Icatibant is administered via subcutaneous injection and is known for its rapid onset of action. The substance has a relatively short half-life, necessitating careful dosing to maintain therapeutic levels. In terms of chemical structure, Icatibant is a nonapeptide, which contributes to its specificity and efficacy in targeting the bradykinin receptor. Its safety profile is generally favorable, with common side effects including injection site reactions and gastrointestinal disturbances. Overall, Icatibant represents a significant advancement in the management of hereditary angioedema, providing patients with a targeted therapeutic option to control acute attacks.

Formula: C₅₉H₈₉N₁₉O₁₃S

InChI: InChI=1/C59H89N19O13S/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,35+,37+,38?,39-,40-,41-,42-,43?,44?,45?,46?/m0/s1

Synonyms:

• Firazyr
• Hoe140
• L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-
• (2S)-2-({[(3aS,7aS)-1-({2-[(2S)-2-{[(2S)-2-({[({(4R)-1-[(1-{2-({(2R)-2-amino-5-[(diaminomethylidene)amino]pentanoyl}amino)-5-[(diaminomethylidene)amino]pentanoyl}pyrrolidin-2-yl)carbonyl]-4-hydroxypyrrolidin-2-yl}carbonyl)amino]acetyl}amino)-3-(thiophen-2-yl)propanoyl]amino}-3-hydroxypropanoyl]-1,2,3,4-tetrahydroisoquinolin-3-yl}carbonyl)octahydro-1H-indol-2-yl]carbonyl}amino)-5-[(diaminomethylidene)amino]pentanoic acid (non-preferred name)

L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-

CAS: 130308-48-4

• Formula: C₅₉H₈₉N₁₉O₁₃S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 1304.5225

Icatibant

CAS: 130308-48-4

Icatibant is a selective and specific antagonist of the bradykinin B2 receptor (IC50 and Ki: …

• Formula: C₅₉H₈₉N₁₉O₁₃S
• Purity: 98%
• Color and Shape: White Solid
• Molecular weight: 1304.52

Icatibant

CAS: 130308-48-4

• Formula: C₅₉H₈₉N₁₉O₁₃S
• Color and Shape: White To Off-White Solid
• Molecular weight: 1304.54

Icatibant

CAS: 130308-48-4

• Formula: C₅₉H₈₉N₁₉O₁₃S
• Purity: ≥ 98.0%
• Color and Shape: White powder
• Molecular weight: 1304.5

Icatibatide Acetate

CAS: 130308-48-4

• Formula: C₅₉H₈₉N₁₉O₁₃S
• Purity: 95%~99%
• Color and Shape: White to Off-white Powder
• Molecular weight: 1304.52

Icatibant

CAS: 130308-48-4

Icatibant is a 10 amino acid peptidomimetic of bradykinin and a selective antagonist to the …

• Formula: C₅₉H₈₉N₁₉O₁₃S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 1,304.52 g/mol

Icatibant Peptide Fragment [1-7] TFA Salt

CAS: 130308-48-4

• Formula: C₃₄H₅₅N₁₃O₁₀S•xC₂HF₃O₂
• Color and Shape: Neat
• Molecular weight: 837.95 + (114.02)x

D-Arginyl-[Hyp3,Thi5,D-Tic7,Oic8]-Bradykinin

CAS: 130308-48-4

Please enquire for more information about D-Arginyl-[Hyp3,Thi5,D-Tic7,Oic8]-Bradykinin including the price, delivery time and more detailed …

• Formula: C₅₉H₈₉N₁₉O₁₃S
• Purity: Min. 95%
• Molecular weight: 1,304.5 g/mol