CAS 130308-48-4

Icatibant

Description:

Icatibant is a synthetic peptide and a selective bradykinin B2 receptor antagonist, primarily used in the treatment of hereditary angioedema, a condition characterized by recurrent episodes of severe swelling. Its mechanism of action involves blocking the effects of bradykinin, a peptide that promotes vasodilation and increases vascular permeability, thereby alleviating the symptoms associated with angioedema. Icatibant is administered via subcutaneous injection and is known for its rapid onset of action. The substance has a relatively short half-life, necessitating careful dosing to maintain therapeutic levels. In terms of chemical structure, Icatibant is a nonapeptide, which contributes to its specificity and efficacy in targeting the bradykinin receptor. Its safety profile is generally favorable, with common side effects including injection site reactions and gastrointestinal disturbances. Overall, Icatibant represents a significant advancement in the management of hereditary angioedema, providing patients with a targeted therapeutic option to control acute attacks.

Formula: C₅₉H₈₉N₁₉O₁₃S

InChI: InChI=1/C59H89N19O13S/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,35+,37+,38?,39-,40-,41-,42-,43?,44?,45?,46?/m0/s1

Synonyms:

• Firazyr
• Hoe140
• L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-
• (2S)-2-({[(3aS,7aS)-1-({2-[(2S)-2-{[(2S)-2-({[({(4R)-1-[(1-{2-({(2R)-2-amino-5-[(diaminomethylidene)amino]pentanoyl}amino)-5-[(diaminomethylidene)amino]pentanoyl}pyrrolidin-2-yl)carbonyl]-4-hydroxypyrrolidin-2-yl}carbonyl)amino]acetyl}amino)-3-(thiophen-2-yl)propanoyl]amino}-3-hydroxypropanoyl]-1,2,3,4-tetrahydroisoquinolin-3-yl}carbonyl)octahydro-1H-indol-2-yl]carbonyl}amino)-5-[(diaminomethylidene)amino]pentanoic acid (non-preferred name)

L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-

CAS: 130308-48-4

Formula: C₅₉H₈₉N₁₉O₁₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 1304.5225

Ref: IN-DA000U9B

Icatibant

CAS: 130308-48-4

Icatibant is a selective and specific antagonist of the bradykinin B2 receptor (IC50 and Ki: 1.07 nM and 0.798 nM respectively).

Formula: C₅₉H₈₉N₁₉O₁₃S

Purity: 98%

Color and Shape: White Solid

Molecular weight: 1304.52

Ref: TM-T15547

Icatibant

CAS: 130308-48-4

Formula: C₅₉H₈₉N₁₉O₁₃S

Color and Shape: White To Off-White Solid

Molecular weight: 1304.54

Ref: 4Z-PI-119001

Icatibant

CAS: 130308-48-4

Formula: C₅₉H₈₉N₁₉O₁₃S

Purity: ≥ 98.0%

Color and Shape: White powder

Molecular weight: 1304.5

Ref: 7W-GK8849

Icatibatide Acetate

CAS: 130308-48-4

Formula: C₅₉H₈₉N₁₉O₁₃S

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 1304.52

Ref: BP-BPPG041

Icatibant

CAS: 130308-48-4

Icatibant is a 10 amino acid peptidomimetic of bradykinin and a selective antagonist to the bradykinin B2 receptor. Icabinant has been used for the treatment of attacks in patients with hereditary angioedema. Recent evidence has shown a link between dysregulated bradykinin‐mediated inflammation and acute respiratory distress syndrome (ARDS), a common complication in COVID-19 patients. Icatibant was proposed to inhibit excessive activation of the bradykinin B2 receptor during the SARS-CoV-2 infection, reducing the risk of ARDS._x000D_

Formula: C₅₉H₈₉N₁₉O₁₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,304.52 g/mol

Ref: 3D-FI45882

Icatibant Peptide Fragment [1-7] TFA Salt

Controlled Product

CAS: 130308-48-4

Formula: C₃₄H₅₅N₁₃O₁₀S•xC₂HF₃O₂

Color and Shape: Neat

Molecular weight: 837.95 + (114.02)x

Ref: TR-R181105

D-Arginyl-[Hyp3,Thi5,D-Tic7,Oic8]-Bradykinin

CAS: 130308-48-4

D-Arginyl-[Hyp3,Thi5,D-Tic7,Oic8]-Bradykinin is a synthetic peptide that is used as a research tool. It has been shown to activate ion channels and receptor proteins in studies on cell biology and pharmacology. This peptide also inhibits the binding of ligands to their receptors, which may be due to its structural similarity with other peptides that bind to the same receptor. D-Arginyl-[Hyp3,Thi5,D-Tic7,Oic8]-Bradykinin is an inhibitor of protein interactions.

Formula: C₅₉H₈₉N₁₉O₁₃S

Purity: Min. 95%

Molecular weight: 1,304.5 g/mol

Ref: 3D-PKB-4293-V