CAS 1303607-07-9

MI-773

Description:

MI-773, identified by its CAS number 1303607-07-9, is a chemical compound that belongs to a class of substances known for their potential applications in medicinal chemistry, particularly in the field of oncology. This compound is characterized by its specific molecular structure, which typically includes functional groups that contribute to its biological activity. MI-773 has been studied for its role as a selective inhibitor, targeting specific pathways involved in cancer cell proliferation and survival. Its mechanism of action often involves modulation of key signaling pathways, making it a candidate for therapeutic development. Additionally, MI-773 may exhibit properties such as solubility in various solvents, stability under certain conditions, and a defined pharmacokinetic profile, which are crucial for its efficacy and safety in clinical applications. As research continues, further insights into its pharmacodynamics, toxicity, and potential side effects are essential for understanding its overall utility in cancer treatment.

Formula: C₂₉H₃₄Cl₂FN₃O₃

Synonyms:

• MI-773
• (2'R,3S,3'S,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide
• (2'R,3S,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-N-((1r,4R)-4-hydroxycyclohexyl)-2'-neop
• Spiro[3H-indole-3,3′-pyrrolidine]-5′-carboxamide, 6-chloro-4′-(3-chloro-2-fluorophenyl)-2′-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2′R,3S,4′S,5′R)-
• (2'R,3S,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxospiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide

MI-773

Controlled Product

CAS: 1303607-07-9

Formula: C₂₉H₃₄Cl₂FN₃O₃

Color and Shape: Neat

Molecular weight: 562.5

Ref: TR-M341105

MI-773

CAS: 1303607-07-9

MI-773 is a small molecule that inhibits the activation of ubiquitin ligases. These enzymes are involved in the regulation of protein degradation, cell cycle progression, and apoptosis. MI-773 has been shown to inhibit cancer cell growth and induce apoptosis in vitro. It also reduces xenograft tumor growth and induces tumor regression in vivo. MI-773 inhibits proliferation by inhibiting the expression of cell cycle regulators such as cyclin D1 and CDK4, which are involved in the regulation of cellular proliferation. This agent also induces apoptotic cell death by activating caspase 3, an enzyme that plays a role in initiating apoptosis.

Formula: C₂₉H₃₄Cl₂FN₃O₃

Purity: Min. 95%

Molecular weight: 562.5 g/mol

Ref: 3D-DCC60707

MI-773

CAS: 1303607-07-9

MI-773 is a potent inhibitor of the MDM2-p53 protein interaction (PPI) with a high affinity for MDM2 and a Kd value of 8.2 nM. MI-773 exhibits antitumour effects.

Formula: C₂₉H₃₄Cl₂FN₃O₃

Color and Shape: Solid

Molecular weight: 562.5

Ref: TM-T63974