CAS 130477-52-0

L-655,708

Description:

L-655,708, with the CAS number 130477-52-0, is a chemical compound that functions primarily as a selective antagonist of the neurokinin-1 (NK1) receptor. This receptor is involved in various physiological processes, including pain perception, stress response, and the regulation of mood. L-655,708 has been studied for its potential therapeutic applications in treating conditions such as anxiety, depression, and pain disorders. The compound is characterized by its ability to bind specifically to the NK1 receptor, inhibiting the action of substance P, a neuropeptide associated with pain and inflammatory responses. In terms of its chemical structure, L-655,708 features a complex arrangement of functional groups that contribute to its pharmacological activity. Its efficacy and safety profile have been evaluated in preclinical studies, highlighting its potential as a valuable tool in neuropharmacology. However, further research is necessary to fully understand its therapeutic potential and any associated side effects.

Formula: C₁₈H₁₉N₃O₄

InChI: InChI=1/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1

SMILES: CCOC(=O)c1c2[C@@H]3CCCN3C(=O)c3cc(ccc3n2cn1)OC

Synonyms:

• 11,12,13,13A-Tetrahydro-7-Methoxy-9-Oxo-9H-Imidazo[1,5-A]Pyrrolo[2,1-C][1,4]Benzodiazepine-1-Carboxylic Acid, Ethyl Ester
• 11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester
• Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate
• ethyl (13aS)-7-methoxy-9-oxo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate
• 9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-methoxy-9-oxo-, ethyl ester, (13aS)-

9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, 11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-, ETHYL ESTER, (13AS)-

CAS: 130477-52-0

Formula: C₁₈H₁₉N₃O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 341.3612

Ref: IN-DA000UGV

L-655708

CAS: 130477-52-0

L-655708

Purity: ≥98%

Molecular weight: 341.36g/mol

Ref: 54-BUP02303

L-655,708

CAS: 130477-52-0

Formula: C₁₈H₁₉N₃O₄

Molecular weight: 341.36

Ref: 7W-GK7274

L-655708

CAS: 130477-52-0

L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.

Formula: C₁₈H₁₉N₃O₄

Purity: 98.41%

Color and Shape: Powder

Molecular weight: 341.36

Ref: TM-TQ0151

L-655708

CAS: 130477-52-0

L-655708 is a benzodiazepine binding inhibitor that binds competitively to the GABA A receptor and blocks the response to GABA. It has been shown to reduce anxiety in mice with a model system of panic disorder. L-655708 has also been shown to have pharmacological activity in mice with brain functions, such as mouse hippocampal, locomotor activity, and receptor binding. L-655708 can be used for treatment of anxiety disorders, such as generalized anxiety disorder (GAD) or panic disorder (PD), and seizures. The drug has a synergistic effect with other drugs that act on GABA receptors, such as benzodiazepines.

Formula: C₁₈H₁₉N₃O₄

Purity: Min. 95%

Molecular weight: 341.36 g/mol

Ref: 3D-FFA47752