CAS 130579-75-8

Eplivanserin

Description:

Eplivanserin is a chemical compound primarily recognized for its role as a selective antagonist of the serotonin 5-HT2A receptor. This compound is notable for its potential therapeutic applications, particularly in the treatment of psychiatric disorders such as schizophrenia and other mood disorders. Eplivanserin exhibits a unique pharmacological profile, which may contribute to its efficacy and safety in clinical settings. The molecular structure of Eplivanserin includes various functional groups that facilitate its interaction with biological targets. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are crucial for determining its suitability for therapeutic use. Additionally, Eplivanserin has been studied for its effects on neurotransmitter systems, which are integral to its mechanism of action. As with many compounds in this class, ongoing research aims to elucidate its full therapeutic potential and side effect profile, ensuring a comprehensive understanding of its role in pharmacotherapy.

Formula: C₁₉H₂₁FN₂O₂

InChI: InChI=1S/C19H21FN2O2/c1-22(2)13-14-24-21-19(17-5-3-4-6-18(17)20)12-9-15-7-10-16(23)11-8-15/h3-12,23H,13-14H2,1-2H3/b12-9+,21-19-

InChI key: InChIKey=VAIOZOCLKVMIMN-PRJWTAEASA-N

SMILES: C(\C=C\C1=CC=C(O)C=C1)(=N/OCCN(C)C)/C2=C(F)C=CC=C2

Synonyms:

• (Z,E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime
• 2-Propen-1-one, 1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-, O-[2-(dimethylamino)ethyl]oxime, (1Z,2E)-
• 2-Propen-1-one, 1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-, O-[2-(dimethylamino)ethyl]oxime, (Z,E)-
• 4-[(2Z)-3-{[2-(dimethylamino)ethoxy]amino}-3-(2-fluorophenyl)prop-2-en-1-ylidene]cyclohexa-2,5-dien-1-one
• Sr 46349
• Eplivanserin

Eplivanserin

CAS: 130579-75-8

Eplivanserin

Purity: ≥95%

Molecular weight: 328.38g/mol

Ref: 54-BUP01647

Eplivanserin

CAS: 130579-75-8

Eplivanserin is a potent and selective 5-HT2C receptor antagonist with pharmacological effects that include long-term efficacy. It has been shown to be effective in experimental models for treating depression, anxiety, and obsessive-compulsive disorder. Eplivanserin is also an antagonist of the α1A subunit of the histamine H1 receptor. It has been shown to reduce locomotor activity in rats and prevent lysis of erythrocytes from human blood by complement. The drug binds to the active site of polymerase chain reaction (PCR) DNA synthesis and blocks transcription elongation. This prevents mRNA transcription and protein synthesis at the ribosome level. Eplivanserin is a 5-HT2C receptor agonist that selectively activates 5-HT2C receptors in the central nervous system, as well as in peripheral tissues such as the gastrointestinal tract, bladder, and uterus. Studies have shown that eplivanser

Formula: C₁₉H₂₁FN₂O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 328.38 g/mol

Ref: 3D-FE102705

Eplivanserin

Controlled Product

CAS: 130579-75-8

Formula: C₁₉H₂₁FN₂O₂

Color and Shape: Neat

Molecular weight: 328.381

Ref: TR-E262545

Eplivanserin

CAS: 130579-75-8

Eplivanserin (SR-46349) is an effective and selective antagonist of 5-HT2A receptor with a Kd of 1.14 nM and an IC50 value of 5.8 nM in rat cortical membrane.

Formula: C₁₉H₂₁FN₂O₂

Purity: 97.04%

Color and Shape: Solid

Molecular weight: 328.38

Ref: TM-T11217