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CAS 130636-43-0

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Nifekalant

Description:
Nifekalant is a chemical compound primarily recognized for its role as an antiarrhythmic agent, particularly in the management of ventricular tachycardia and fibrillation. It is classified as a class III antiarrhythmic drug, which means it primarily works by blocking potassium channels, thereby prolonging the action potential and refractory period in cardiac tissues. This mechanism helps to stabilize heart rhythm and prevent abnormal electrical activity. Nifekalant is typically administered intravenously and is notable for its rapid onset of action. The compound has a relatively high affinity for cardiac ion channels, which contributes to its effectiveness in acute settings. In terms of physical properties, Nifekalant is a synthetic organic compound with specific solubility characteristics that facilitate its use in clinical settings. Its safety profile and pharmacokinetics have been studied, although it is essential to consider potential side effects and contraindications when used in patients. Overall, Nifekalant represents a significant therapeutic option in the field of cardiology for managing serious arrhythmias.
Formula:C19H27N5O5
InChI:InChI=1S/C19H27N5O5/c1-21-17(14-18(26)22(2)19(21)27)20-9-11-23(12-13-25)10-3-4-15-5-7-16(8-6-15)24(28)29/h5-8,14,20,25H,3-4,9-13H2,1-2H3
InChI key:InChIKey=OEBPANQZQGQPHF-UHFFFAOYSA-N
SMILES:N(CCN(CCCC1=CC=C(N(=O)=O)C=C1)CCO)C=2N(C)C(=O)N(C)C(=O)C2
Synonyms:
  • 2,4(1H,3H)-pyrimidinedione, 6-[[2-[(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-
  • 6-((2-((2-Hydroxyethyl)(3-(4-nitrophenyl)propyl)amino)ethyl)amino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione
  • 6-((2-((2-Hydroxyethyl)(3-(4-nitrophenyl)propyl)amino)ethyl)amino)-1,3-dimethyluracil
  • 6-[(2-{(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino}ethyl)amino]-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
  • 6-[(2-{(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino}ethyl)amino]-1,3-dimethylpyrimidine-2,4(1H,3H)-dione hydrochloride (1:1)
  • Nifekalant
  • Nifekalant [INN]
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