CAS 130656-51-8

Nifekalant hydrochloride

Description:

Nifekalant hydrochloride is a pharmaceutical compound primarily used as an antiarrhythmic agent, particularly in the management of ventricular tachyarrhythmias. It is classified as a class III antiarrhythmic drug, which means it works by prolonging the cardiac action potential and refractory period, thereby stabilizing the heart's rhythm. The compound is characterized by its ability to block potassium channels, specifically the rapid component of the delayed rectifier potassium current, which is crucial for cardiac repolarization. Nifekalant hydrochloride is typically administered intravenously due to its rapid onset of action, making it suitable for acute situations. The hydrochloride salt form enhances its solubility and stability, facilitating its use in clinical settings. As with many medications, potential side effects may include hypotension, bradycardia, and other cardiac-related issues, necessitating careful monitoring during administration. Overall, Nifekalant hydrochloride represents a significant therapeutic option in the field of cardiology for managing life-threatening arrhythmias.

Formula: C₁₉H₂₇N₅O₅·ClH

InChI: InChI=1S/C19H27N5O5.ClH/c1-21-17(14-18(26)22(2)19(21)27)20-9-11-23(12-13-25)10-3-4-15-5-7-16(8-6-15)24(28)29;/h5-8,14,20,25H,3-4,9-13H2,1-2H3;1H

InChI key: InChIKey=YPVGGQKNWAKOPX-UHFFFAOYSA-N

SMILES: N(CCN(CCCC1=CC=C(N(=O)=O)C=C1)CCO)C=2N(C)C(=O)N(C)C(=O)C2.Cl

Synonyms:

• 1,3-Dimethyl-6-[2-(N-(2-Hydroxyethyl)-3-(4-Nitrophenyl)Propylamino)Ethylamino]-2,4(1H,3H)-Pyrimidinedione Hydrochloride
• 2,4(1H,3H)-Pyrimidinedione, 6-[[2-[(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-, hydrochloride (1:1)
• 2,4(1H,3H)-Pyrimidinedione, 6-[[2-[(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-, monohydrochloride
• Ms 551
• Nifekalant Hcl
• Nifekalant [6-((2-((2-Hydroxyethyl)(3-(P-Nitrophenyl)Propyl)Amino)Ethyl)Amino)-1,3-Dimethyl-Uracil]
• Shinbit
• Nifekalant hydrochloride
• Nifekalant Hydrochloride
• ms551
• NIFEKALANT

2,4(1H,3H)-Pyrimidinedione, 6-[[2-[(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-, hydrochloride (1:1)

CAS: 130656-51-8

Formula: C₁₉H₂₈ClN₅O₅

Purity: 99.92%

Color and Shape: Solid

Molecular weight: 441.9091

Ref: IN-DA000URC

Nifekalant hydrochloride

CAS: 130656-51-8

Formula: C₁₉H₂₈ClN₅O₅

Molecular weight: 441.91

Ref: 7W-GP4286

Nifekalant hydrochloride

CAS: 130656-51-8

Nifekalant hydrochloride

Purity: ≥98%

Molecular weight: 441.91g/mol

Ref: 54-BUP10527

Nifekalant HCl

CAS: 130656-51-8

Formula: C₁₉H₂₇N₅O₅·HCl

Color and Shape: Yellow Solid

Molecular weight: 405.46 36.46

Ref: 4Z-N-083001

Nifekalant HCl

CAS: 130656-51-8

Potassium channel blocker; class III anti-arrhythmic agent

Formula: C₁₉H₂₈ClN₅O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 441.91 g/mol

Ref: 3D-FN65104

Nifekalant Hydrochloride

CAS: 130656-51-8

Applications Nifekalant Hydrochloride is a class III antiarrhythmic agent. Nifekalant Hydrochloride is used in the treatment of patients with extensive anterior infarction and severe ventricular dysfunction.
References Takenaka, K. Jap. Circ. J., 65, 60 (2001); Igawa, M. et al.: J. Cardio. Pharmacol., 40, 735 (2002); Washizuka, T. et al.: Circ. J., 69, 1508 (2005);

Formula: C₁₉H₂₇N₅O₅·ClH

Color and Shape: Light Yellow Solid

Molecular weight: 441.9091

Ref: TR-N457100

Nifekalant hydrochloride

CAS: 130656-51-8

Nifekalant hydrochloride is an IKr potassium channel blocker with an IC50 of 10 µM.

Formula: C₁₉H₂₈ClN₅O₅

Purity: 99.91%

Color and Shape: Solid

Molecular weight: 441.91

Ref: TM-T2712