CAS 1306760-87-1

Ozanimod

Description:

Ozanimod is a selective sphingosine 1-phosphate receptor modulator, primarily targeting S1P receptors 1 and 5. It is utilized in the treatment of certain autoimmune conditions, notably multiple sclerosis and ulcerative colitis. The compound exhibits a unique mechanism of action by modulating lymphocyte trafficking, effectively reducing the number of circulating lymphocytes and thereby mitigating inflammatory responses. Ozanimod is characterized by its oral bioavailability and a relatively long half-life, allowing for once-daily dosing. Its chemical structure includes a bicyclic core, contributing to its specificity and potency. The substance has undergone extensive clinical trials, demonstrating efficacy in reducing disease activity and improving patient outcomes. As with many pharmacological agents, potential side effects may include infections, liver enzyme elevations, and cardiovascular effects, necessitating careful monitoring during treatment. Overall, Ozanimod represents a significant advancement in the therapeutic landscape for managing chronic inflammatory diseases.

Formula: C₂₃H₂₄N₄O₃

InChI: InChI=1S/C23H24N4O3/c1-14(2)29-21-9-6-15(12-16(21)13-24)23-26-22(27-30-23)19-5-3-4-18-17(19)7-8-20(18)25-10-11-28/h3-6,9,12,14,20,25,28H,7-8,10-11H2,1-2H3/t20-/m0/s1

InChI key: InChIKey=XRVDGNKRPOAQTN-FQEVSTJZSA-N

SMILES: N(CCO)[C@@H]1C=2C(=C(C=CC2)C=3N=C(ON3)C4=CC(C#N)=C(OC(C)C)C=C4)CC1

Synonyms:

• Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-
• Ozanimod
• 5-[3-[1-(S)-(2-Hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-isopropoxybenzonitrile
• 5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile
• RPC 1063

Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-

CAS: 1306760-87-1

Formula: C₂₃H₂₄N₄O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 404.4617

Ref: IN-DA000USL

Ozanimod

CAS: 1306760-87-1

Formula: C₂₃H₂₄N₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 404.47

Ref: 4Z-O-077001

Ozanimod

CAS: 1306760-87-1

Ozanimod

Purity: ≥98%

Molecular weight: 404.46g/mol

Ref: 54-BUP15181

Ozanimod-d6

CAS: 1306760-87-1

Formula: C₂₃H₁₈D₆N₄O₃

Molecular weight: 410.51

Ref: 4Z-O-077002

Ozanimod

CAS: 1306760-87-1

Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator.

Formula: C₂₃H₂₄N₄O₃

Purity: 98.68% - 99.58%

Color and Shape: Solid

Molecular weight: 404.46

Ref: TM-T6923

Ozanimod

CAS: 1306760-87-1

Formula: C₂₃H₂₄N₄O₃

Color and Shape: Neat

Molecular weight: 404.46

Ref: TR-O880000

Ozanimod-d7

Controlled Product

CAS: 1306760-87-1

Applications Ozanimod-d7 is the labeled analogue of Ozanimod (O880000), which is an agonist that binds to S1P1 and S1P5 receptors. Experiments on rodents revealed that Ozanimod is effective against autoimmune diseases.
References Scott, F. L., et al.: Br. J. Pharmacol., 173, 1778 (2016)

Formula: C₂₃D₇H₁₇N₄O₃

Color and Shape: Neat

Molecular weight: 411.505

Ref: TR-O880002

Ozanimod

CAS: 1306760-87-1

Sphingosine 1-phosphate receptor (S1P1R and S1P5R) agonist

Formula: C₂₃H₂₄N₄O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 404.46 g/mol

Ref: 3D-FO162376