CAS 13071-11-9

(R)-propranolol hydrochloride

Description:

(R)-propranolol hydrochloride is a non-selective beta-adrenergic antagonist primarily used in the treatment of hypertension, anxiety, and certain types of heart conditions. It is the hydrochloride salt of (R)-propranolol, which is the active enantiomer of the racemic mixture propranolol. This compound exhibits a lipophilic nature, allowing it to cross the blood-brain barrier, which contributes to its efficacy in managing anxiety and migraine prophylaxis. The chemical structure features a naphthalene ring system, a secondary amine, and an alcohol group, which are crucial for its pharmacological activity. (R)-propranolol hydrochloride is typically administered orally and is known for its relatively rapid onset of action. Its pharmacokinetics include extensive hepatic metabolism, leading to a variable bioavailability. Common side effects may include fatigue, dizziness, and gastrointestinal disturbances. As with any medication, it is essential to consider contraindications and potential interactions with other drugs. Overall, (R)-propranolol hydrochloride is a significant therapeutic agent in cardiovascular and psychiatric medicine.

Formula: C₁₆H₂₁NO₂

InChI: InChI=1/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H/t14-;/m0./s1

InChI key: InChIKey=ZMRUPTIKESYGQW-PFEQFJNWSA-N

SMILES: O(C[C@@H](CNC(C)C)O)C=1C2=C(C=CC1)C=CC=C2.Cl

Synonyms:

• (+)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride
• (+)-Anapriline
• (+)-Propranolol hydrochloride
• (2R)-1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol hydrochloride (1:1)
• (2S)-1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol hydrochloride (1:1)
• (R)-1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride
• 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, hydrochloride, (+)-
• 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride (1:1), (2R)-
• 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (2R)-
• 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (R)-
• Ay 20694
• Dexpropranolol hydrochloride
• Ici 47319
• R-(+)-1-Isopropylamino-3-(1-naphthoxy)-2-propanol hydrochloride
• d-Anapriline
• d-Propranolol hydrochloride
• (R)-(+)-Propranolol hydrochloride
• (R)-(+)-PROPANOLOL HYDROCHLORIDE
• (R)-(+)-1-[(1-METHYLETHYL)AMINO]-3-(1-NAPHTHALENYLOXY)-2-PROPANOL HYDROCHLORIDE
• R-PROPANOLOL
• (R)-(+)-PROPRANOLOL
• 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (2R)-(9CI)
• 2R-(+)-PROPANOLOL HYDROCHLORIDE
• (R)-[2-hydroxy-3-(naphthyloxy)propyl]isopropylammonium chloride
• R-(+)-PROPANOLOL HCL
• 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, hydrochloride, (+)-(8CI)
• (R)-(+)-1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-2-PROPANOL HYDROCHLORIDE
• R-PROPRANOLOL
• (R)-1-ISOPROPYLAMINO-3-(1-NAPHTHYLOXY)-2-PROPANOL HYDROCHLORIDE

(R)-(+)-Propranolol HCl

CAS: 13071-11-9

Formula: C₁₆H₂₂ClNO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 295.8044

Ref: IN-DA00HS8T

(R)-(+)-Propranolol hydrochloride

CAS: 13071-11-9

Formula: C₁₀H₇OCH₂CH(OH)CH₂NHCH(CH₃)₂·HCl

Molecular weight: 295.80

Ref: 7W-GK0630

(R)-Propranolol HCl

CAS: 13071-11-9

Formula: C₁₆H₂₁NO₂·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 259.35 36.46

Ref: 4Z-P-177

(R)-Propranolol hydrochloride

CAS: 13071-11-9

(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol.

Formula: C₁₆H₂₂ClNO₂

Purity: 98.63% - 99.01%

Color and Shape: Solid

Molecular weight: 295.8

Ref: TM-T20898

(R)-Propranolol Hydrochloride

Controlled Product

CAS: 13071-11-9

Applications The R-enantiomer of Propranolol (P831800). β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),

Formula: C₁₆H₂₂ClNO₂

Color and Shape: White Solid

Molecular weight: 295.8

Ref: TR-P831790

(R)-Propranolol

CAS: 13071-11-9

Formula: C₁₆H₂₁NO₂HCl

Molecular weight: 259.35 : 36.46

Ref: ST-EA-CP-P31018