CAS 13073-21-7
:L-buthionine
Description:
L-buthionine, also known as L-buthionine sulfoximine (BSO), is a synthetic compound primarily recognized for its role as a selective inhibitor of the enzyme gamma-glutamylcysteine synthetase. This enzyme is crucial in the biosynthesis of glutathione, a vital antioxidant in cellular defense against oxidative stress. L-buthionine is characterized by its ability to deplete intracellular levels of glutathione, thereby influencing various biochemical pathways and cellular responses. It is often utilized in research settings to study the effects of glutathione depletion on cell viability, apoptosis, and drug resistance, particularly in cancer studies. The compound is typically administered in vitro or in vivo to investigate its pharmacological effects. L-buthionine is soluble in water and exhibits stability under physiological conditions, making it a valuable tool in biochemical and pharmacological research. However, its use requires careful consideration of its potential cytotoxic effects due to the reduction of antioxidant defenses in cells.
Formula:C8H17NO2S
InChI:InChI=1/C8H17NO2S/c1-2-3-5-12-6-4-7(9)8(10)11/h7H,2-6,9H2,1H3,(H,10,11)/t7-/m0/s1
SMILES:CCCCSCC[C@@H](C(=O)O)N
Synonyms:- S-butyl-L-homocysteine
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