CAS 13073-25-1

2-Bromo-6-nitrophenol

Description:

2-Bromo-6-nitrophenol is an organic compound characterized by the presence of both bromine and nitro functional groups attached to a phenolic ring. Its molecular structure features a bromine atom at the second position and a nitro group at the sixth position of the phenol ring, which significantly influences its chemical properties. This compound typically appears as a yellow to orange crystalline solid and is known for its moderate solubility in organic solvents and limited solubility in water. 2-Bromo-6-nitrophenol exhibits acidic properties due to the hydroxyl group, allowing it to participate in various chemical reactions, including nucleophilic substitutions and electrophilic aromatic substitutions. It is often used in organic synthesis and as an intermediate in the production of dyes, pharmaceuticals, and agrochemicals. Additionally, the presence of both the bromine and nitro groups can enhance its reactivity and alter its electronic properties, making it a valuable compound in research and industrial applications. Safety precautions should be taken when handling this compound, as it may pose health risks.

Formula: C₆H₄BrNO₃

InChI: InChI=1/C6H4BrNO3/c7-4-2-1-3-5(6(4)9)8(10)11/h1-3,9H

SMILES: c1cc(c(c(c1)N(=O)=O)O)Br

Synonyms:

• 2-Bromo-6-Nitro Phenol
• 2-Nitro-6-bromophenol

2-Bromo-6-nitrophenol

CAS: 13073-25-1

Formula: C₆H₄BrNO₃

Purity: >98.0%(GC)(T)

Color and Shape: Light yellow to Amber to Dark green powder to crystal

Molecular weight: 218.01

Ref: 3B-B2203

2-Bromo-6-nitrophenol, 97%

CAS: 13073-25-1

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₆H₄BrNO₃

Purity: 97%

Color and Shape: White to yellow to brown, Crystals or powder or crystalline powder

Molecular weight: 218.01

Ref: 02-H27326

Phenol, 2-bromo-6-nitro-

CAS: 13073-25-1

Formula: C₆H₄BrNO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 218.0049

Ref: IN-DA000UWH

2-Bromo-6-nitrophenol

CAS: 13073-25-1

2-Bromo-6-nitrophenol

Formula: C₆H₄BrNO₃

Purity: 98%

Color and Shape: bright yellow/lime crystals

Molecular weight: 218.00g/mol

Ref: 54-OR9738

2-Bromo-6-nitrophenol

CAS: 13073-25-1

2-Bromo-6-nitrophenol undergoes transformation into 2-bromo-6-aminophenol, which is subsequently converted to N-acetyl-2-bromo-6-aminophenol.

Formula: C₆H₄BrNO₃

Color and Shape: Solid

Molecular weight: 218

Ref: TM-T38704

2-Bromo-6-nitrophenol

CAS: 13073-25-1

2-Bromo-6-nitrophenol is a synthetic chemical that is used as an intermediate in the synthesis of other chemicals. It can be prepared by reacting ammonium formate with hydroxyl group of 2-bromo-6-nitropyridine. The reaction yield can be improved by activating the hydroxyl group and removing impurities through a dehydration reaction. The time required for the reaction to occur can be shortened by using acetonitrile as a solvent instead of water. This chemical is also synthesized by coupling metal salts with nitro groups or amines, which are called Suzuki coupling reactions.

Formula: C₆H₄BrNO₃

Color and Shape: Powder

Molecular weight: 218 g/mol

Ref: 3D-FB45449

2-Bromo-6-nitrophenol

CAS: 13073-25-1

Formula: C₆H₄BrNO₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 218.006

Ref: 10-F034301

2-Bromo-6-nitrophenol

Controlled Product

CAS: 13073-25-1

Applications 2-Bromo-6-nitrophenol is an intermediate used in the synthesis of N-Hydroxy Eltrombopag (H825795), which is a derivative compound of Eltrombopag (508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.
References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),

Formula: C₆H₄BrNO₃

Color and Shape: Neat

Molecular weight: 218.01

Ref: TR-B698010