JWH-073 6-hydroxyindole metabolite is a synthetic cannabinoid that is a derivative of the indole structure, specifically related to the JWH series of compounds. This substance is characterized by its ability to interact with cannabinoid receptors in the brain, primarily the CB1 receptor, which is associated with the psychoactive effects of cannabinoids. The presence of a hydroxyl group at the 6-position of the indole ring is significant, as it may influence the compound's pharmacological properties and metabolic pathways. As a metabolite, it is typically formed in the body after the administration of JWH-073, a compound known for its recreational use and potential for abuse. The safety profile, toxicity, and long-term effects of this metabolite are not well-documented, reflecting the broader concerns regarding synthetic cannabinoids, which can exhibit unpredictable effects and pose health risks. Due to its classification and potential legal implications, research on JWH-073 6-hydroxyindole metabolite is limited, necessitating caution in its use and further investigation into its biological effects.

JWH 073 is a mildly selective agonist of the central cannabinoid (CB
1
) receptor derived from the aminoalkylindole WIN 55,212-
2. The K
i
values for binding CB
1
and the peripheral cannabinoid (CB
2
) receptor are 8.9 and 38 nM, respectively for a CB
1
:CB
2
ratio of 0.23. JWH 073 is one of several synthetic cannabinoids which have been included in smoking mixtures. JWH 073 6-
hydroxyindole metabolite is expected to be a urinary metabolite of JWH 073 based on the metabolism of the closely-
related JWH 015 and JWH 018.

JWH 073 6-hydroxyindole metabolite

1307803-48-0: JWH-073 6-hydroxyindole metabolite is a synthetic cannabinoid that is a derivative of the indole structure, specifically related to the JWH series of compounds. This substance is characterized by its ability to interact with cannabinoid receptors in the brain, primarily the CB1 receptor, which is associated with the psychoactive effects of cannabinoids. The presence of a hydroxyl group at the 6-position of the indole ring is significant, as it may influence the compound's pharmacological properties and metabolic pathways. As a metabolite, it is typically formed in the body after the administration of JWH-073, a compound known for its recreational use and potential for abuse. The safety profile, toxicity, and long-term effects of this metabolite are not well-documented, reflecting the broader concerns regarding synthetic cannabinoids, which can exhibit unpredictable effects and pose health risks. Due to its classification and potential legal implications, research on JWH-073 6-hydroxyindole metabolite is limited, necessitating caution in its use and further investigation into its biological effects.

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CAS 1307803-48-0

JWH 073 6-hydroxyindole metabolite

JWH 073 6-hydroxyindole metabolite

Ref: 3D-HCC80348