CAS 1309283-24-6

N-Trityl Losartan-d4

Description:

N-Trityl Losartan-d4 is a deuterated derivative of Losartan, an angiotensin II receptor antagonist commonly used in the treatment of hypertension and heart failure. The "N-Trityl" designation indicates that a trityl group is attached to the nitrogen atom of the Losartan molecule, which can enhance its stability and solubility. The "d4" signifies that the compound contains four deuterium atoms, which are isotopes of hydrogen, replacing standard hydrogen atoms in the structure. This modification is often utilized in pharmacokinetic studies and metabolic research to trace the compound's behavior in biological systems. N-Trityl Losartan-d4 retains the core pharmacophore of Losartan, allowing it to interact with the angiotensin II receptor, but the presence of deuterium can alter its metabolic pathways and half-life. Overall, this compound is significant in both therapeutic applications and research settings, particularly in understanding drug metabolism and receptor interactions.

Formula: C₄₁H₃₇ClN₆O

Synonyms:

• N-Trityl Losartan-d4
• Trityllosartan-d4
• 2-Butyl-4-chloro-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl-d4]-4-yl]Methyl]-1H-iMidazole-5-Methanol

N-Trityl Losartan-d4

Controlled Product

CAS: 1309283-24-6

Applications A protected form of labelled Losartan (an antihypertensive).
References Srimurugan, S., et al.: Chem. Pharm. Bull., 56, 383 (2008),

Formula: C₄₁H₃₃D₄ClN₆O

Color and Shape: Neat

Molecular weight: 669.25

Ref: TR-T888822

N-Trityl losartan-d4

CAS: 1309283-24-6

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Formula: C₄₁H₃₇ClN₆O

Purity: Min. 95%

Molecular weight: 669.2 g/mol

Ref: 3D-JCC28324