Benzyl-PEG2-CH2CO2tBu, identified by its CAS number 1309451-06-6, is a chemical compound that features a polyethylene glycol (PEG) moiety linked to a benzyl group and a tert-butyl ester of a carboxylic acid. The presence of the PEG segment imparts hydrophilicity, enhancing solubility in aqueous environments, while the benzyl group contributes to its lipophilicity and potential for interaction with biological systems. The tert-butyl ester group provides stability and can be hydrolyzed under specific conditions, releasing the corresponding carboxylic acid. This compound is often utilized in bioconjugation, drug delivery systems, and as a linker in the synthesis of various biomaterials due to its favorable properties, including biocompatibility and the ability to modify surface characteristics. Its structure allows for versatility in applications, particularly in the fields of pharmaceuticals and materials science, where controlled release and targeted delivery are essential.

Benzyl-PEG2-CH2CO2tBu is a PEG linker containing a benzyl group and a t-butyl protected carbonyl. Both the benzyl and t-Butyl group can be removed under acidic conditions. The carboxylic acid can be reacted with primary amines in the presence of activators such as EDC and DCC to form stable amide bonds. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.

Benzyl-PEG2-CH2CO2tBu

1309451-06-6: Benzyl-PEG2-CH2CO2tBu, identified by its CAS number 1309451-06-6, is a chemical compound that features a polyethylene glycol (PEG) moiety linked to a benzyl group and a tert-butyl ester of a carboxylic acid. The presence of the PEG segment imparts hydrophilicity, enhancing solubility in aqueous environments, while the benzyl group contributes to its lipophilicity and potential for interaction with biological systems. The tert-butyl ester group provides stability and can be hydrolyzed under specific conditions, releasing the corresponding carboxylic acid. This compound is often utilized in bioconjugation, drug delivery systems, and as a linker in the synthesis of various biomaterials due to its favorable properties, including biocompatibility and the ability to modify surface characteristics. Its structure allows for versatility in applications, particularly in the fields of pharmaceuticals and materials science, where controlled release and targeted delivery are essential.

BnO-PEG1-CH2CO2tBu is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

CAS 1309451-06-6

Benzyl-PEG2-CH2CO2tBu

Benzyl-PEG2-CH2CO2tBu

Ref: IN-DA00HSA6

BnO-PEG1-CH2CO2tBu

Ref: TM-T14696

Benzyl-PEG2-CH2CO2tBu

Ref: 54-BIPG1190