CAS 13095-47-1

D-2-Hydroxyglutaric acid

Description:

D-2-Hydroxyglutaric acid, also known as D-2-hydroxyglutarate, is a chiral organic compound that plays a significant role in various biochemical processes. It is a derivative of glutaric acid and is characterized by the presence of a hydroxyl group at the second carbon position. This compound exists as a white crystalline solid and is soluble in water, making it accessible for various biological and chemical applications. D-2-Hydroxyglutaric acid is particularly notable for its involvement in cellular metabolism, where it can act as a metabolite in the citric acid cycle. It has garnered attention in the context of certain metabolic disorders and has been studied for its potential implications in cancer biology, particularly in relation to mutations in the isocitrate dehydrogenase (IDH) enzymes. The compound's stereochemistry is crucial, as the D-enantiomer is distinct from its L-counterpart, which can have different biological activities. Overall, D-2-hydroxyglutaric acid is an important compound in both metabolic pathways and clinical research.

Formula: C₅H₈O₅

InChI: InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/t3-/m1/s1

InChI key: InChIKey=HWXBTNAVRSUOJR-GSVOUGTGSA-N

SMILES: [C@@H](CCC(O)=O)(C(O)=O)O

Synonyms:

• (2R)-2-Hydroxypentanedioic acid
• D-α-Hydroxyglutaric acid
• Pentanedioic acid, 2-hydroxy-, (2R)-
• Glutaric acid, 2-hydroxy-, D-
• Pentanedioic acid, 2-hydroxy-, (R)-

2-hydroxypentanedioic acid

CAS: 13095-47-1

Formula: C₅H₈O₅

Purity: 90%

Color and Shape: Solid

Molecular weight: 148.1140

Ref: IN-DA009W9J

(R)-2-Hydroxypentanedioic Acid

CAS: 13095-47-1

(R)-2-Hydroxypentanedioic Acid

Purity: 90%

Molecular weight: 148.11g/mol

Ref: 54-OR1024026

(2R)-2-Hydroxypentanedioic acid

CAS: 13095-47-1

(2R)-2-Hydroxypentanedioic acid is a metabolite of 2-hydroxyglutarate that is produced in the metabolism of glucose. This compound has been shown to be elevated in gliomas and may serve as a diagnostic marker for this type of cancer. A mutation in isocitrate dehydrogenase, an enzyme that catalyzes the conversion of isocitrate to alpha-ketoglurate, has been shown to be associated with gliomas. This mutation leads to accumulation of (2R)-2-hydroxypentanedioic acid and increases the risk for this type of cancer. The elevated levels of (2R)-2-hydroxypentanedioic acid can be used as a biomarker for disease activity and diagnosis.

Formula: C₅H₈O₅

Purity: Min. 95%

Molecular weight: 148.11 g/mol

Ref: 3D-NAA09547