CAS 1309684-94-3

RO8994

Description:

RO8994, identified by its CAS number 1309684-94-3, is a chemical compound that has garnered interest in the field of medicinal chemistry, particularly for its potential therapeutic applications. While specific details about its characteristics may vary, compounds like RO8994 typically exhibit properties such as a defined molecular structure, which influences their reactivity and interaction with biological systems. These substances are often characterized by their solubility in various solvents, stability under different conditions, and specific functional groups that dictate their chemical behavior. Additionally, RO8994 may have a particular mechanism of action, potentially targeting specific biological pathways or receptors, making it a candidate for drug development. Safety and toxicity profiles are also crucial characteristics, as they determine the compound's suitability for use in clinical settings. Overall, the study of RO8994 involves understanding its chemical properties, biological activity, and potential applications in therapeutic contexts.

Formula: C₃₁H₃₁Cl₂FN₄O₄

Synonyms:

• (2'S,3R,4'S,5'R)-N-[4-(Aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide
• CS-2264
• RO8994
• Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-
• RO-8994;RO 8994
• RO8994;RO-8994;RO 8994

RO8994

CAS: 1309684-94-3

RO8994

Purity: ≥98%

Molecular weight: 613.51g/mol

Ref: 54-BUP02385

RO8994

CAS: 1309684-94-3

RO8994: potent MDM2 spiroindolinone inhibitor, IC50: 20 nM (proliferation), 5 nM (binding).

Formula: C₃₁H₃₁Cl₂FN₄O₄

Purity: 99.31% - 99.44%

Color and Shape: Solid

Molecular weight: 613.51

Ref: TM-T3517

RO 8994

CAS: 1309684-94-3

RO 8994 is a MDM2 inhibitor that has been shown to inhibit the proliferation of myeloproliferative disorders. It has been found to be an effective treatment for primary myelofibrosis, which is characterized by excessive production of blood cells in the bone marrow. The drug blocks the binding of interferons to their receptors, which leads to reduced levels of interferon-induced proteins and decreased expression of PD-L1 on T cells. This drug also inhibits the production and release of cytokines from T cells, which may lead to cancer and other autoimmune diseases. RO 8994 is a non-nucleoside with a novel mechanism of action that binds to the pd-1 receptor and prevents its activation.

Formula: C₃₁H₃₁Cl₂FN₄O₄

Purity: Min. 95%

Molecular weight: 613.51 g/mol

Ref: 3D-JCC68494