CAS 1310693-92-5

Tubastatin A HCl salt

Description:

Tubastatin A HCl salt is a small molecule inhibitor primarily known for its role as a selective inhibitor of histone deacetylases (HDACs), particularly HDAC6. This compound is derived from natural sources and has garnered interest in the field of cancer research due to its potential to induce apoptosis in cancer cells and enhance the efficacy of other therapeutic agents. As a hydrochloride salt, it is typically more soluble in aqueous solutions, which can facilitate its use in biological studies. Tubastatin A exhibits a relatively low molecular weight and possesses a specific structural configuration that allows it to interact effectively with its target enzymes. Its mechanism of action involves the modulation of acetylation levels of histones and non-histone proteins, thereby influencing gene expression and cellular processes. Additionally, studies have indicated that Tubastatin A may have neuroprotective effects, making it a candidate for research in neurodegenerative diseases. Overall, Tubastatin A HCl salt represents a promising avenue for therapeutic development in oncology and neurology.

Formula: C₂₀H₂₁N₃O₂·HCl

Synonyms:

• Tubastatin A hydrochloride
• N-hydroxy-4-((2-methyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)methyl)benzamide hydrochloride
• TSA HCl
• Tubastatin A HCl, >=98%
• Tubastatin A hydrochloride ISO 9001：2015 REACH
• TUBASTATIN A HYDROCHLORIDE;TSA HCL
• Tubastatin A HCl, 98%, a potent and selective HDAC6 inhibitor
• N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
• N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride Tubastatin A HCl
• Tubastatin A HCl salt
• Tubastatin A HCl (AG-CR-13900, TubA)
• N-Hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5 -yl)methyl]benzamide hydrochloride (1:1)
• Tubastatin A hydrochloride N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
• Tubastatin A Hydrochloride (Also See: T897000)
• N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide hydrochloride
• CS-1894

Benzamide, N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-, hydrochloride (1:1)

CAS: 1310693-92-5

Formula: C₂₀H₂₂ClN₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 371.8606

Ref: IN-DA000VH3

Tubastatin A Hydrochloride

CAS: 1310693-92-5

Tubastatin A Hydrochloride

Purity: ≥95%

Molecular weight: 371.86g/mol

Ref: 54-BUP15430

Tubastatin A Hydrochloride

CAS: 1310693-92-5

Tubastatin A Hydrochloride (TSA HCl) is an effective and specific HDAC6 inhibitor (IC50: 15 nM).

Formula: C₂₀H₂₁N₃O₂·HCl

Purity: 97.24% - 99.15%

Color and Shape: Solid

Molecular weight: 371.86

Ref: TM-T6161

Tubastatin A HCl

CAS: 1310693-92-5

Potent inhibitor of histone deacetylase 6 (HDAC6), inducing elevated levels of acetylated α-tubulin. It inhibits pro-inflammatory cytokines TNF-α and IL-6 as well as nitric oxide secretion in human and murine macrophages. It is not neurotoxic and it rescues cognitive impairment in mice model for Alzheimer’s disease.

Formula: C₂₀H₂₁N₃O₂·HCl

Purity: Min. 95%

Color and Shape: White To Brown Solid

Molecular weight: 371.86 g/mol

Ref: 3D-FT65198

Benzamide, N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-, hydrochloride (1:1)

CAS: 1310693-92-5

Purity: ≥98%

Molecular weight: 371.8699951

Ref: 10-F861709

Tubastatin A Hydrochloride

CAS: 1310693-92-5

Stability Hygroscopic
Applications Tubastatin A Hydrochloride is a neuroprotective HDAC6 inhibitor and is also known to induce hyperacetylation in primary cortical neuron cultures.
References Cenik, B., et al.: J. Biol. Chem., 286, 16101 (2011);

Formula: C₂₀H₂₂ClN₃O₂

Color and Shape: Neat

Molecular weight: 371.86

Ref: TR-T897010