CAS 1311143-71-1
:JH295
Description:
As of my last update in October 2023, there is limited publicly available information regarding the chemical substance identified as JH295 with the CAS number 1311143-71-1. This compound may be a research chemical or a proprietary substance, which often means that detailed characteristics such as its molecular structure, physical properties, and specific applications may not be widely documented in standard chemical databases. Typically, substances like this could be used in various fields such as pharmaceuticals, materials science, or chemical research, but without specific data, it is challenging to provide precise characteristics. For accurate and comprehensive information, including safety data, reactivity, and potential uses, consulting specialized chemical literature or databases, or reaching out to the manufacturer or research institution associated with JH295 would be advisable. Always ensure to handle any chemical substance with appropriate safety measures and protocols.
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Found 3 products.
JH295
CAS:<p>JH295: potent, selective Nek2 inhibitor (IC50 = 770 nM), irreversibly targets Cys22, no effect on Cdk1, Aurora B, Plk1, or spindle mechanisms.</p>Formula:C18H16N4O2Color and Shape:SolidMolecular weight:320.352JH295
CAS:<p>JH295 is a small molecule that is a noncatalytic inhibitor of the methyltransferase DNMT1. It binds to the active site of the enzyme, preventing it from carrying out its catalytic function. JH295 has been shown to be effective in treating cancer cells in vitro and in vivo by inhibiting DNA methylation and leading to tumor cell death. JH295 also inhibits Dnmt3a, a protein that is necessary for maintaining DNA methylation patterns, thereby causing hypomethylation. The therapeutic potential of JH295 is supported by its ability to induce hematological responses in animals with leukemia and lymphoma. This drug has been shown to have no effect on the cellular level when used as a hydrogen bond donor or acceptor.</p>Formula:C18H16N4O2Purity:Min. 95%Molecular weight:320.3 g/mol
