CAS 131147-81-4

Hirullin

Description:

Hirullin, with the CAS number 131147-81-4, is a synthetic peptide that has garnered interest primarily for its potential therapeutic applications. It is derived from the natural anticoagulant hirudin, which is produced by leeches. Hirullin exhibits properties that inhibit thrombin, an enzyme critical in the coagulation cascade, thereby demonstrating anticoagulant activity. This characteristic makes it a candidate for use in preventing and treating thrombotic disorders. The peptide's structure typically includes a sequence of amino acids that contribute to its biological activity and specificity for thrombin. Additionally, Hirullin may possess other biological activities, such as anti-inflammatory effects, although research is ongoing to fully elucidate its mechanisms and potential applications. Its stability, solubility, and bioavailability are important factors that influence its therapeutic efficacy. As with many peptides, the development of Hirullin for clinical use involves considerations of synthesis, formulation, and delivery methods to ensure optimal performance in medical applications.

Formula: C₆₈H₆N₁₄O₂

Synonyms:

• H-Ser-Asp-Phe-Glu-Glu-Phe-Ser-Leu-Asp-Asp-Ile-Glu-Gln-OH

Hirullin

CAS: 131147-81-4

Hirullin, originally isolated from the leech Hirudinaria manillensis, is a hirudin-based fibrinogen recognition peptide inhibitor, which binds efficiently to thrombin (IC₅₀= 4.2 µM, in bovine).

Formula: C₆₈H₉₆N₁₄O₂₉

Purity: 98.2%

Color and Shape: White

Molecular weight: 1573.59

Ref: 01-4025345

Hirullin P18

CAS: 131147-81-4

Hirullin P18 is a potent thrombin inhibitor with anticoagulant properties [1].

Formula: C₆₈H₉₆N₁₄O₂₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 1573.57

Ref: TM-T80097

Hirullin

CAS: 131147-81-4

Hirullin H-Ser-Asp-Phe-Glu-Glu-Phe-Ser-Leu-Asp-Asp-Ile-Glu-Gln is a peptide with a carboxy terminal and carbonyl group. It has minimal inhibitory concentrations of about 100 nM for most bacteria and is active against the majority of Gram positive bacteria. Hirullin H is composed of amino acid sequences that are similar to the sequences of active substances in other compounds, such as hirulog, an anticoagulant, and heparin, an antithrombotic drug. Hirullin H has been shown to have bifunctional properties by inhibiting thrombin, which is responsible for blood clotting, while also inhibiting platelet activation.

Formula: C₆₈H₉₆N₁₄O₂₉

Purity: Min. 95%

Molecular weight: 1,573.57 g/mol

Ref: 3D-FH108568