CAS 131179-95-8

Efaproxiral

Description:

Efaproxiral, also known by its chemical name RSR13, is a synthetic compound primarily studied for its potential use in enhancing the efficacy of radiotherapy in cancer treatment. It functions as a hemoglobin modifier, specifically designed to reduce the oxygen affinity of hemoglobin, thereby increasing the availability of oxygen to hypoxic tumor tissues. This mechanism is crucial because many tumors exhibit low oxygen levels, which can lead to resistance against radiation therapy. Efaproxiral is characterized by its ability to improve tumor oxygenation, potentially leading to improved therapeutic outcomes. The compound has a molecular formula that reflects its complex structure, and it is typically administered intravenously. Its pharmacokinetics involve rapid distribution and elimination, which are important for its therapeutic application. While efaproxiral has shown promise in clinical trials, its use is subject to ongoing research to fully understand its efficacy and safety profile in various cancer types.

Formula: C₂₀H₂₃NO₄

InChI: InChI=1S/C20H23NO4/c1-13-9-14(2)11-16(10-13)21-18(22)12-15-5-7-17(8-6-15)25-20(3,4)19(23)24/h5-11H,12H2,1-4H3,(H,21,22)(H,23,24)

InChI key: InChIKey=BNFRJXLZYUTIII-UHFFFAOYSA-N

SMILES: O(C(C(O)=O)(C)C)C1=CC=C(CC(NC2=CC(C)=CC(C)=C2)=O)C=C1

Synonyms:

• 2-(4-(((3,5-Dimethylanilino)Carbonyl)Methyl)Phenoxy)-2-Methylpropionic Acid
• 2-(4-{2-[(3,5-Dimethylphenyl)Amino]-2-Oxoethyl}Phenoxy)-2-Methylpropanoic Acid
• 2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid
• 2-[4-[[[(3,5-Dimethylphenyl)amino]carbonyl]methyl]phenoxy]-2-methylpropionic acid
• Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-
• Rsr 13
• Efaproxiral

Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-

CAS: 131179-95-8

Formula: C₂₀H₂₃NO₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 341.4009

Ref: IN-DA000VN6

Efaproxiral

CAS: 131179-95-8

Efaproxiral

Purity: ≥98%

Molecular weight: 341.4g/mol

Ref: 54-BUP20905

Efaproxiral

Controlled Product

CAS: 131179-95-8

Applications Allosteric modifier of hemoglobin (HB). Binds in the central water cavity of the Hb molecule causing a conformational change such that bound oxygen is released more readily. Antineoplastic adjunct (radiosensitizer).
References Abraham, D.J., et al.: Biochemistry, 31, 9141 (1992), Pagel, P.S., et al.: J. Pharmacol. Exp. Ther., 285, 1 (1998), Kleinberg, L., et al.: J. Clin. Oncol., 17, 2593 (1999),

Formula: C₂₀H₂₃NO₄

Color and Shape: Neat

Molecular weight: 341.40

Ref: TR-E415000

Efaproxiral

CAS: 131179-95-8

Efaproxiral (RSR13) is a hemoglobin allosteric modulator, a potential radiation sensitizer and chemotherapy enhancer, improving tumor oxygenation.

Formula: C₂₀H₂₃NO₄

Purity: 98.98%

Color and Shape: Solid

Molecular weight: 341.4

Ref: TM-T21318

Efaproxiral

Controlled Product

CAS: 131179-95-8

Haemoglobin (Hb) synthetic allosteric modifier

Formula: C₂₀H₂₃NO₄

Purity: Min. 95%

Molecular weight: 341.4 g/mol

Ref: 3D-FE22644