CAS 131275-93-9

(3R,5S)-Atorvastatin sodium salt

Description:

(3R,5S)-Atorvastatin sodium salt is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce cardiovascular risk. It functions as an HMG-CoA reductase inhibitor, effectively decreasing cholesterol synthesis in the liver. The compound is characterized by its chiral centers, which contribute to its specific biological activity and pharmacokinetics. Atorvastatin exhibits high oral bioavailability and is extensively metabolized in the liver, primarily by cytochrome P450 enzymes. Its solubility is influenced by the sodium salt form, enhancing its stability and absorption in the gastrointestinal tract. The drug is typically administered in tablet form and is known for its efficacy in lowering low-density lipoprotein (LDL) cholesterol levels while also having beneficial effects on high-density lipoprotein (HDL) cholesterol. Common side effects may include muscle pain, liver enzyme alterations, and gastrointestinal disturbances. Overall, atorvastatin is a widely prescribed medication with a well-established safety and efficacy profile in the management of dyslipidemia.

Formula: C₃₃H₃₄FN₂NaO₅

Synonyms:

• Atorvastatin 10-Trans

Atorvastatin EP Impurity B Sodium Salt

CAS: 131275-93-9

Formula: C₃₃H₃₄FN₂O₅·Na

Molecular weight: 557.64 22.99

Ref: 4Z-A-1231

(3R,5S)-Atorvastatin sodium salt

CAS: 131275-93-9

(3R,5S)-Atorvastatin sodium salt is a synthetic compound that is used in the treatment of high cholesterol. It belongs to the class of statins, which are used for lowering blood cholesterol levels. The drug product contains at least 99% by weight of (3R,5S)-atorvastatin sodium salt. This product also has an analytical purity greater than 98%. It is metabolized via oxidation and hydroxylation to form metabolites that exhibit pharmacological activity similar to the parent molecule. (3R,5S)-Atorvastatin sodium salt is a natural product that can be found in plants such as yew trees. This drug has been shown to have niche applications in drug development and research and development.

Formula: C₃₃H₃₄FN₂NaO₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 580.62 g/mol

Ref: 3D-IA18022

(3R,5S)-Atorvastatin Sodium Salt

Controlled Product

CAS: 131275-93-9

Stability Hygroscopic
Applications Atorvastatin impurity in bulk drug and tablets.
References Posvar, E., et al.: J. Clin. Pharmacol., 36, 728 (1996), Lea, A., et al.: Drugs, 53, 828 (1997), Miao, X., et al.: J. Chromatogr., 998, 133 (2003),

Formula: C₃₃H₃₄FN₂O₅·Na

Color and Shape: Neat

Molecular weight: 580.62

Ref: TR-A791725