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CAS 1313206-42-6

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Polatuzumab vedotin

Description:
Polatuzumab vedotin is an antibody-drug conjugate (ADC) designed for targeted cancer therapy, specifically for the treatment of certain types of non-Hodgkin lymphoma. It consists of a monoclonal antibody that targets the CD79b protein, which is expressed on the surface of B cells, linked to a cytotoxic agent, monomethyl auristatin E (MMAE). This conjugation allows for selective delivery of the cytotoxic drug directly to cancer cells, minimizing damage to healthy tissues. Polatuzumab vedotin is administered intravenously and is typically used in combination with other therapies to enhance its efficacy. The drug's mechanism involves binding to CD79b, internalization of the conjugate, and subsequent release of MMAE, which disrupts microtubule formation, leading to cell cycle arrest and apoptosis in malignant cells. Clinical studies have demonstrated its effectiveness in patients with relapsed or refractory diffuse large B-cell lymphoma, contributing to its approval for therapeutic use. As with many cancer treatments, potential side effects may include neutropenia, fatigue, and peripheral neuropathy, necessitating careful monitoring during treatment.
Formula:Unspecified
Synonyms:
  • Polatuzumab vedotin
  • DCDS 4501A
  • Immunoglobulin G1, anti-(human gene B29 protein) (human-Mus musculus monoclonal MCDS4409A heavy chain), disulfide with human-Mus musculus monoclonal MCDS4409A κ-chain, dimer, thioether with N-[[[4-[[N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
  • FCU 2711
  • Immunoglobulin G1, anti-(human antigen CD79b) (human-Mus musculus monoclonal MCDS4409A heavy chain), disulfide with human-Mus musculus monoclonal MCDS4409A κ-chain, dimer, thioether with maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E
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