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CAS 1313390-76-9

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(4R)-Fmoc-4-phenoxy-L-proline

Description:
(4R)-Fmoc-4-phenoxy-L-proline is a synthetic amino acid derivative characterized by its unique structure, which includes a phenoxy group and a fluorenylmethyloxycarbonyl (Fmoc) protecting group. This compound is primarily utilized in peptide synthesis, particularly in the solid-phase synthesis of peptides, due to its ability to protect the amino group while allowing for further coupling reactions. The Fmoc group is known for its stability under basic conditions and can be easily removed under mild acidic conditions, making it advantageous for sequential peptide synthesis. The presence of the phenoxy group contributes to the compound's hydrophobic characteristics, influencing the overall solubility and reactivity in various solvents. Additionally, the chirality at the proline residue plays a crucial role in determining the conformation and biological activity of the resulting peptides. Overall, (4R)-Fmoc-4-phenoxy-L-proline is a valuable building block in the field of medicinal chemistry and peptide research.
Formula:C26H23NO5
Synonyms:
  • (4R)-Fmoc-4-phenoxy-L-proline
  • (2S,4R)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-4-phenoxypyrrolidine-2-carboxylic acid
  • 1,2-Pyrrolidinedicarboxylic acid, 4-phenoxy-, 1-(9H-fluoren-9-ylmethyl) ester, (2S,4R)-
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