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CAS 1313706-14-7

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Pinatuzumab vedotin

Description:
Pinatuzumab vedotin is an antibody-drug conjugate (ADC) designed for targeted cancer therapy. It consists of a monoclonal antibody that specifically binds to the CD79b antigen, which is predominantly expressed on B-cell malignancies, linked to a potent cytotoxic agent, monomethyl auristatin E (MMAE). This conjugation allows for selective delivery of the cytotoxic drug directly to cancer cells, minimizing damage to healthy tissues. Pinatuzumab vedotin is primarily investigated for its efficacy in treating various forms of non-Hodgkin lymphoma and other B-cell malignancies. The mechanism of action involves internalization of the antibody-drug complex upon binding to CD79b, followed by the release of MMAE inside the cancer cell, leading to disruption of microtubule dynamics and subsequent cell death. The drug's pharmacokinetics, safety profile, and therapeutic potential are subjects of ongoing clinical research, aiming to improve outcomes for patients with resistant or relapsed B-cell cancers. As with many ADCs, the balance between efficacy and toxicity is a critical consideration in its development and application.
Formula:Unspecified
Synonyms:
  • FCU 2703
  • Immunoglobulin G1, anti-(human antigen CD22) (human-Mus musculus monoclonal MCDT2219A heavy chain), disulfide with human-Mus musculus monoclonal MCDT2219A κ-chain, dimer, thioether with maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl monomethylauristatin E
  • RO 5541072-000
  • Immunoglobulin G1, anti-(human sialic acid-binding immunoglobulin-like lectin 2) (human-Mus musculus monoclonal MCDT2219A heavy chain), disulfide with human-Mus musculus monoclonal MCDT2219A κ-chain, dimer, thioether with N-[[[4-[[N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
  • Pinatuzumab vedotin
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