Description:Amyloid beta-protein fragment 1-38, often referred to as Aβ1-38, is a peptide associated with Alzheimer's disease and is a component of amyloid plaques found in the brains of affected individuals. This fragment is derived from the larger amyloid precursor protein (APP) and consists of 38 amino acids. Aβ1-38 is known for its ability to aggregate, forming oligomers and fibrils, which are implicated in neurotoxicity and the progression of Alzheimer's pathology. The peptide exhibits hydrophobic characteristics, contributing to its propensity to aggregate in aqueous environments. Additionally, it can interact with various cellular receptors and proteins, influencing neuronal signaling and health. The CAS number 131438-74-9 uniquely identifies this specific peptide in chemical databases, facilitating research and study. Understanding the properties and behavior of Aβ1-38 is crucial for developing therapeutic strategies aimed at mitigating its harmful effects in neurodegenerative diseases.
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