CAS 131602-53-4

amyloid B-protein fragment 25-35

Description:

Amyloid beta-protein fragment 25-35 (often referred to as Aβ25-35) is a peptide derived from the amyloid precursor protein (APP) and is significant in the study of Alzheimer's disease. This fragment consists of 11 amino acids and is known for its role in the formation of amyloid plaques, which are characteristic of Alzheimer's pathology. Aβ25-35 is particularly notable for its neurotoxic properties, as it can induce oxidative stress and promote neuronal cell death. The peptide is often used in research to model the effects of amyloid beta in neurodegenerative processes. Its structure allows for aggregation, leading to the formation of fibrils that can disrupt cellular function. Additionally, Aβ25-35 has been implicated in the modulation of synaptic activity and may influence cognitive functions. Understanding the characteristics and behavior of this fragment is crucial for developing therapeutic strategies aimed at mitigating the effects of amyloid beta in Alzheimer's disease and related disorders.

Formula: C₄₅H₈₁N₁₃O₁₄S

InChI: InChI=1/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)/t24-,25-,26-,27-,28-,29-,30-,31-,36-,37-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=NCC(=N[C@@H](CC(C)C)C(=N[C@@H](CCSC)C(=O)O)O)O)O)N=C([C@H]([C@@H](C)CC)N=C([C@H](C)N=C(CN=C([C@H](CCCCN)N=C([C@H](CC(=N)O)N=C([C@H](CO)N=C(CN)O)O)O)O)O)O)O

Synonyms:

• Amyloid Beta-Protein (Human, 25-35) Trifluoroacetate
• Beta-Amyloid(25-35)
• Abeta 25-35

Amyloid β (25-35)

CAS: 131602-53-4

For cellular and molecular biology applications

Color and Shape: Powder, White to off-white

Ref: 02-J66808

Amyloid β-Protein (25-35)

CAS: 131602-53-4

The biologically active domain of the amyloid β-protein for neurotrophic and neurotoxic effects is located in the β (25-35) sequence GSNKGAIIGLM, which is homologous to a region in peptides of the tachykinin family.

Formula: C₄₅H₈₁N₁₃O₁₄S

Purity: 97.0%

Color and Shape: White Powder

Molecular weight: 1060.28

Ref: 01-4030205

β-Amyloid (25-35)

CAS: 131602-53-4

β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.

Formula: C₄₅H₈₁N₁₃O₁₄S

Purity: 97.91%

Color and Shape: Solid

Molecular weight: 1060.27

Ref: TM-T14284

Amyloid β Protein fragment 25-35

CAS: 131602-53-4

Amyloid β Protein fragment 25-35

Purity: ≥97%

Molecular weight: 1,060.27g/mol

Ref: 54-BIBA1010

β-Amyloid (25-35)

CAS: 131602-53-4

β-Amyloid (25-35)

Purity: ≥95%

Molecular weight: 1060.27g/mol

Ref: 54-BUP01506

Amyloid beta-Protein (25-35) trifluoroacetate salt

CAS: 131602-53-4

Amyloid beta-protein (Aβ) is a protein that is a major component of amyloid plaques in the brains of people with Alzheimer's disease. Aβ-Protein (25-35) trifluoroacetate salt, also known as Aβ(25-35), is an amyloid beta protein fragment that has been shown to inhibit neuronal death and increase antioxidative properties in human serum. It has been shown to have anti-apoptotic effects by inhibiting the activation of caspases and the release of cytochrome C from mitochondria. This drug may have physiological effects on the central nervous system due to its ability to induce apoptosis through mitochondrial membrane depolarization and cytosolic calcium levels. It has been shown to be active against Chinese herb Pueraria lobata and cell lysis, as well as granule neurons in culture. It may also stimulate phosphorylation of p38mapk and induce logarithmic growth

Formula: C₄₅H₈₁N₁₃O₁₄S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,060.27 g/mol

Ref: 3D-FA108377

AMYLOID β-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE

CAS: 131602-53-4

Formula: C₄₅H₈₁N₁₃O₁₄S

Purity: 97%

Color and Shape: Solid

Molecular weight: 1060.268340000001

Ref: IN-DA009ATE

Amyloid Beta-Protein (Human, 25-35)

CAS: 131602-53-4

Amyloid beta-Protein (Human, 25-35) is the shortest amyloid fragment that forms β-sheet fibrils, while retaining toxicity, and may also induce the aggregation of N-tau protein and N-tau peptide 1/2R. Consequently this peptide may play a role in the pathogenesis of Alzheimer's disease, a neurodegenerative disorder that affects memory and cognitive function.
This product is available as a trifluoroacetate salt and as a 0.5mg vial.

Formula: C₄₅H₈₁N₁₃O₁₄S

Purity: Min. 95%

Molecular weight: 1,060.3 g/mol

Ref: 3D-PAM-4309-V