CAS 1316059-00-3

Formula: C18H19ClN6O4S2

InChI: InChI=1S/C18H19ClN6O4S2/c1-3-30(26,27)15-6-5-13(31(28,29)20-2)8-14(15)24-17-9-18(23-11-22-17)25-16-7-4-12(19)10-21-16/h4-11,20H,3H2,1-2H3,(H2,21,22,23,24,25)

InChI key: OEDGERSSZUMLBI-UHFFFAOYSA-N

SMILES: CCS(=O)(=O)C1=C(C=C(C=C1)S(=O)(=O)NC)NC2=NC=NC(=C2)NC3=NC=C(C=C3)Cl

GSK854

CAS: 1316059-00-3

GSK854

Formula: C₁₈H₁₉ClN₆O₄S₂

Purity: ≥98%

Molecular weight: 482.96

Ref: 54-BUP07295

3-((6-((5-chloropyridin-2-yl)amino)pyrimidin-4-yl)amino)-4-(ethylsulfonyl)-N-methylbenzenesulfonamide

CAS: 1316059-00-3

Formula: C₁₈H₁₉ClN₆O₄S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 482.9643

Ref: IN-DA01EAQ2

GSK854

CAS: 1316059-00-3

3-((6-((5-Chloropyridin-2-yl)amino)pyrimidin-4-yl)amino)-4-(ethylsulfonyl)-N-methylbenzenesulfonamide

Formula: C₁₈H₁₉ClN₆O₄S₂

Purity: 98+%

Molecular weight: 482.96

Ref: IN-DG297586

GSK 854

CAS: 1316059-00-3

Molecular probe for understanding the biology of troponin I-interacting kinase (TNNI3K) and its role in heart failure. The compound exhibits substantial selectivity for TNNI3K over homologous kinases B-Raf and EGFR. In vivo studies showed reduced ROS and p38 MAP kinase activation in mice models for myocardial infarction resulting in reduced left ventricular dysfunction and improved remodelling.

Formula: C₁₈H₁₉ClN₆O₄S₂

Purity: Min. 95%

Molecular weight: 482.97 g/mol

Ref: 3D-BG165704

GSK854

CAS: 1316059-00-3

GSK854 is a selective TNNI3K inhibitor reducing heart damage and stress post-infarction in mice.

Formula: C₁₈H₁₉ClN₆O₄S₂

Purity: 98.91%

Color and Shape: White Solid

Molecular weight: 482.964

Ref: TM-T24115