CAS 1316214-52-4

ACY-1215

Description:

ACY-1215, also known by its chemical name, is a selective inhibitor of the enzyme histone deacetylase 6 (HDAC6). This compound is notable for its potential therapeutic applications, particularly in the treatment of various cancers and neurodegenerative diseases. ACY-1215 functions by modulating the acetylation status of histones and non-histone proteins, which can influence gene expression and cellular processes such as apoptosis and cell cycle regulation. The compound has shown promise in preclinical studies, demonstrating the ability to enhance the efficacy of other anticancer agents and to promote the degradation of misfolded proteins, which is particularly relevant in neurodegenerative conditions. Its specificity for HDAC6 over other HDAC isoforms is a key characteristic, as it may lead to fewer side effects compared to broader-spectrum HDAC inhibitors. Additionally, ACY-1215 is being investigated for its potential to improve immune responses in cancer therapy, making it a compound of interest in ongoing research within the fields of oncology and neurology.

Formula: C₂₄H₂₇N₅O₃

Synonyms:

• Rocilinostat

7-{[2-(Diphenylamino)pyrimidin-5-yl]formamido}-N-hydroxyheptanamide

CAS: 1316214-52-4

Formula: C₂₄H₂₇N₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 433.5029

Ref: IN-DA000ZIN

Ricolinostat

CAS: 1316214-52-4

Ricolinostat

Purity: ≥95%

Molecular weight: 433.5g/mol

Ref: 54-BUP15489

Ricolinostat

CAS: 1316214-52-4

Ricolinostat (Rocilinostat) is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity.

Formula: C₂₄H₂₇N₅O₃

Purity: 97.17% - 99.76%

Color and Shape: Solid

Molecular weight: 433.5

Ref: TM-T2489

2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide

Controlled Product

CAS: 1316214-52-4

Applications This compound acts as a selective HDAC-6 (histone deacetylase) inihibitor. HDAC is linked to the transcription of DNA in cancers, including multiple myeloma (MM).
References Santo, L. et al.: Blood, 119, 2579 (2012);

Formula: C₂₄H₂₇N₅O₃

Color and Shape: Off-White

Molecular weight: 433.51

Ref: TR-D486990

ACY 1215

CAS: 1316214-52-4

Rocilinostat (ACY-1215) is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity.

Formula: C₂₄H₂₇N₅O₃

Purity: Min. 95%

Molecular weight: 433.5 g/mol

Ref: 3D-BA164806