CAS 1316215-12-9

HDAC-IN-2

Description:

HDAC-IN-2, with the CAS number 1316215-12-9, is a chemical compound that functions as a histone deacetylase (HDAC) inhibitor. HDAC inhibitors are known for their role in modifying the acetylation status of histones, which can influence gene expression and cellular processes. This compound is characterized by its ability to selectively inhibit certain HDAC enzymes, thereby promoting the acetylation of histones and non-histone proteins. The resulting changes in gene expression can have significant implications in various biological contexts, including cancer therapy, neurodegenerative diseases, and other conditions where epigenetic regulation is disrupted. HDAC-IN-2 is often studied for its potential therapeutic applications, particularly in enhancing the efficacy of existing treatments or in combination therapies. Additionally, its chemical structure typically includes functional groups that facilitate binding to the active site of HDAC enzymes, contributing to its inhibitory activity. As with many HDAC inhibitors, the specificity and potency of HDAC-IN-2 can vary depending on the particular HDAC isoforms targeted.

Formula: C₂₄H₂₆ClN₅O₃

Synonyms:

• 2-((2-Chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide
• N-(6-(hydroxycarbamoyl)hexyl)-2-(N-(2-chlorophenyl)-N-phenylamino)pyrimidine-5-carboxamide
• HDAC-IN-2
• ACY-241(CITARINOSTAT)
• (Z)-2-((2-chlorophenyl)(phenyl)amino)-N-((Z)-7-hydroxy-7-(hydroxyimino)heptyl)pyrimidine-5-carbimidic acid
• CS-1760
• Citarinostat
• Citarinostat(ACY-241,HDAC-IN-2)
• ACY-241; ACY 241; ACY241; HDAC-IN-2; CITARINOSTAT.
• 5-Pyrimidinecarboxamide, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-
• (Z)-2-((2-CHLOROPHENYL)(PHENYL)AMINO)-N-((Z)-7-HYDROXY-7-(HYDROXYIMINO)HEPTYL)PYRIMIDINE-5-CARBIMIDIC ACID;HDAC-IN-2
• Citarinostat (ACY-241)

5-Pyrimidinecarboxamide, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-

CAS: 1316215-12-9

Formula: C₂₄H₂₆ClN₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 467.9479

Ref: IN-DA000ZIL

Citarinostat

CAS: 1316215-12-9

Citarinostat

Purity: ≥95%

Molecular weight: 467.95g/mol

Ref: 54-BUP02829

Citarinostat

CAS: 1316215-12-9

Formula: C₂₄H₂₆ClN₅O₃

Molecular weight: 467.95

Ref: 4Z-C-271001

Citarinostat

CAS: 1316215-12-9

ACY-241 (Citarinostat), a potent oral HDAC inhibitor, may induce tumor cell death and block growth by altering gene expression.

Formula: C₂₄H₂₆ClN₅O₃

Purity: 98.06% - 99.06%

Color and Shape: Solid

Molecular weight: 467.95

Ref: TM-T3661

Citarinostat-d5

CAS: 1316215-12-9

Formula: C₂₄H₂₁D₅ClN₅O₃

Molecular weight: 472.98

Ref: 4Z-C-271002

ACY-241

CAS: 1316215-12-9

ACY-241 is an experimental drug that may be used to treat cancer. It works by inhibiting the activity of enzymes that are essential in the apoptosis pathway. ACY-241 has minimal toxicity and has been shown to have synergistic effects on tumor cells with other drugs. This drug has been shown to inhibit tumor cell growth in vitro and in vivo, as well as to reduce tumor size in mice with prostate cancer. ACY-241 also binds to a monoclonal antibody that targets mitochondrial membrane potential and inhibits the growth of prostate cancer cells.

Formula: C₂₄H₂₆ClN₅O₃

Purity: Min. 95%

Molecular weight: 467.95 g/mol

Ref: 3D-RCC21512