CAS 1316845-74-5

3’-Deoxy-3’-fluorothymidine-5’-monophosphate Disodium Salt

Description:

3’-Deoxy-3’-fluorothymidine-5’-monophosphate disodium salt, often abbreviated as FdUMP, is a nucleotide analog that plays a significant role in molecular biology and pharmacology. This compound is characterized by the presence of a fluorine atom at the 3' position of the thymidine base, which alters its biochemical properties compared to natural nucleotides. As a monophosphate, it contains a phosphate group attached to the 5' carbon of the sugar moiety, which is crucial for its function in nucleic acid synthesis and metabolism. The disodium salt form enhances its solubility in aqueous solutions, making it suitable for various laboratory applications. FdUMP is particularly notable for its role as an inhibitor of thymidylate synthase, an enzyme critical for DNA synthesis, thereby making it a valuable compound in cancer therapy, especially in the context of fluoropyrimidine-based treatments. Its unique structure allows it to mimic natural nucleotides, facilitating its incorporation into DNA and influencing cellular processes.

Formula: C₁₀H₁₂FN₂Na₂O₇P

Synonyms:

• 3'-Deoxy-3'-fluoro-
• 3’-Deoxy-3’-fluorothymidine-5’-monophosphate Disodium Salt

3'-Deoxy-3'-fluorothymidine-5'-monophosphate disodium salt

CAS: 1316845-74-5

3'-Deoxy-3'-fluorothymidine-5'-monophosphate disodium salt is a novel antiviral drug. 3'-Deoxy-3'-fluorothymidine-5'-monophosphate disodium salt is a nucleoside analog and is synthesized by modification of the 5' phosphate group of thymidine with fluorine and chlorine. 3'-Deoxy-3'-fluorothymidine-5'-monophosphate disodium salt inhibits viral replication by competing with natural substrates for incorporation into viral DNA. It has shown to be effective in vitro against influenza A, herpes simplex virus type 1, and cytomegalovirus. 3'-Deoxy-3'-fluorothymidine-5'-monophosphate disodium salt also has anticancer properties due to its ability to inhibit DNA synthesis in human tumor cells.

Formula: C₁₀H₁₂FN₂Na₂O₇P

Purity: Min. 95%

Molecular weight: 368.16 g/mol

Ref: 3D-ND63287

3’-Deoxy-3’-fluorothymidine-5’-monophosphate Disodium Salt

Controlled Product

CAS: 1316845-74-5

Applications A thymidine-5'-O-monophosphate analogue as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
References Jong, A., et al.: J. Biol. Chem., 259, 11052 ( 1984), Choi, Y., et al.: J. Med. Chem., 43, 2538 (2000), Stokstad, E., et al.: Science, 287, 2391 (2000), Li de La Sierra, I., et al.: J. Mol. Biol., 311, 87 (2001),

Formula: C₁₀H₁₂FN₂Na₂O₇P

Color and Shape: Neat

Molecular weight: 368.16

Ref: TR-D235480