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CAS 131740-09-5

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FLAVOPIRIDOL HYDROCHLORIDE

Description:
Flavopiridol hydrochloride is a synthetic flavonoid derivative that primarily functions as a potent inhibitor of cyclin-dependent kinases (CDKs), which are crucial for cell cycle regulation. This compound is characterized by its ability to interfere with the phosphorylation of proteins involved in cell cycle progression, making it a subject of interest in cancer research and therapy. Flavopiridol hydrochloride is typically presented as a white to off-white powder and is soluble in water and various organic solvents. Its mechanism of action involves the induction of apoptosis in cancer cells, thereby inhibiting tumor growth. The substance has been investigated in clinical trials for its efficacy in treating various malignancies, including hematological cancers. Additionally, it has shown potential in combination therapies, enhancing the effectiveness of other anticancer agents. Safety and toxicity profiles are essential considerations in its application, as with any chemotherapeutic agent. Overall, flavopiridol hydrochloride represents a significant advancement in targeted cancer treatment strategies.
Formula:C21H20ClNO5·ClH
InChI:InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m0./s1
InChI key:InChIKey=LGMSNQNWOCSPIK-LWHGMNCYSA-N
SMILES:OC=1C(=C2C(C(=O)C=C(O2)C3=C(Cl)C=CC=C3)=C(O)C1)[C@@H]4[C@H](O)CN(C)CC4.Cl
Synonyms:
  • (3R,4S)-4-[2-(2-chlorophenyl)-5,7-dihydroxy-4-oxo-4H-chromen-8-yl]-3-hydroxy-1-methylpiperidinium chloride
  • 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one hydrochloride
  • 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, cis-(-)-
  • 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride
  • 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1)
  • Alvocidib Hydrochloride
  • Flavopiridol Hcl
  • HL 275 hydrochloride
  • HMR 1275 hydrochloride
  • Hl 275
  • See more synonyms
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