CAS 131796-63-9

Odapipam

Description:

Odapipam, with the CAS number 131796-63-9, is a chemical compound that functions primarily as a selective antagonist of the dopamine D4 receptor. It is part of a class of compounds that have been investigated for their potential therapeutic applications in various neuropsychiatric disorders, including schizophrenia and attention-deficit hyperactivity disorder (ADHD). Odapipam exhibits a high affinity for the D4 receptor, which is implicated in the modulation of mood, cognition, and behavior. The compound's structure includes a piperazine moiety, which is common in many pharmacologically active substances. Its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are crucial for determining its efficacy and safety profile in clinical settings. Research into Odapipam has focused on its ability to influence dopaminergic pathways, potentially leading to improved outcomes in conditions characterized by dopaminergic dysregulation. As with any pharmacological agent, understanding its mechanism of action and side effects is essential for its therapeutic application.

Formula: C₁₉H₂₀ClNO₂

InChI: InChI=1/C19H20ClNO2/c1-21-7-5-13-9-17(20)18(22)10-15(13)16(11-21)14-4-2-3-12-6-8-23-19(12)14/h2-4,9-10,16,22H,5-8,11H2,1H3/t16-/m1/s1

SMILES: CN1CCc2cc(c(cc2[C@H](C1)c1cccc2CCOc12)O)Cl

Synonyms:

• Odapipam [INN]
• (+)-(S)-8-Chloro-5-(2,3-dihydro-7-benzofuranyl)-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepin-7-ol
• Nnc 01-0756
• Nnc 756
• Unii-847Pqf7Zn6
• (5S)-8-chloro-5-(2,3-dihydro-1-benzofuran-7-yl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ol

Odapipam

CAS: 131796-63-9

Odapipam is a diagnostic agent for the detection of drugs or metabolites in animal tissues. It is a non-radioactive, water-soluble, fluorescent probe that binds to hydroxyl groups on proteins and lipids. Odapipam has been used to characterize liver function by detecting specific drug binding sites in rat liver microsomes. This probe can also be used for prognosis of hepatic disease, as well as for the diagnosis of various cancers. Odapipam has been shown to be a linker between two molecules, which allows it to bind two molecules together with high specificity and affinity. Odapipam is reconstituted in acidic solution at pH 5.5 and diluted further with water or saline before use.br>br>
Odapipam is available as a pharmaceutical dosage form containing 1 mg of odapipam hydrochloride per mL in 20% hydroxypropyl beta-cyclodextrin (HPBCD)

Formula: C₁₉H₂₀ClNO₂

Purity: Min. 95%

Molecular weight: 329.8 g/mol

Ref: 3D-GFA79663

Odapipam

CAS: 131796-63-9

Odapipam is a selective and high affinity antagonist of benzazepine dopamine D1 receptor (Kd of 0.18 nM).

Formula: C₁₉H₂₀ClNO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 329.82

Ref: TM-T12288