CAS 13192-04-6

Dimethyl 2-oxoglutarate

Description:

Dimethyl 2-oxoglutarate is an organic compound characterized by its structure, which features two methyl ester groups attached to the 2-oxoglutarate backbone. It is a derivative of 2-oxoglutaric acid, a key intermediate in the Krebs cycle, and plays a significant role in various metabolic processes. This compound is typically a colorless to pale yellow liquid with a pleasant odor. It is soluble in organic solvents and exhibits moderate solubility in water. Dimethyl 2-oxoglutarate is often used in biochemical research and as a reagent in organic synthesis, particularly in the preparation of other chemical compounds. Its reactivity is influenced by the presence of the carbonyl groups, making it a useful building block in the synthesis of more complex molecules. Additionally, it may have applications in the pharmaceutical industry due to its potential biological activity. As with many chemical substances, proper handling and safety precautions are essential, as it may pose health risks if ingested or inhaled.

Formula: C₇H₁₀O₅

InChI: InChI=1S/C7H10O5/c1-11-6(9)4-3-5(8)7(10)12-2/h3-4H2,1-2H3

InChI key: InChIKey=TXIXSLPEABAEHP-UHFFFAOYSA-N

SMILES: C(CCC(OC)=O)(C(OC)=O)=O

Synonyms:

• 1,5-Dimethyl 2-oxopentanedioate
• 2-Ketoglutaric acid dimethyl ester
• 2-Oxoglutaric acid dimethyl ester
• Dimethyl 2-Oxopentanedioate
• Dimethyl α-ketoglutarate
• Dimethyl α-oxoglutarate
• Glutaric acid, 2-oxo-, dimethyl ester
• Pentanedioic acid, 2-oxo-, 1,5-dimethyl ester
• Pentanedioic acid, 2-oxo-, dimethyl ester
• α-Ketoglutaric acid dimethyl ester
• Dimethyl 2-oxoglutarate

Dimethyl 2-Oxoglutarate

CAS: 13192-04-6

Formula: C₇H₁₀O₅

Purity: >95.0%(GC)

Color and Shape: Colorless to Light yellow to Light orange clear liquid

Molecular weight: 174.15

Ref: 3B-K0013

Pentanedioic acid, 2-oxo-, 1,5-dimethyl ester

CAS: 13192-04-6

Formula: C₇H₁₀O₅

Purity: 97%

Color and Shape: Liquid

Molecular weight: 174.1513

Ref: IN-DA000ZX1

TUN-92046

CAS: 13192-04-6

TUN-92046

Purity: ≥95%

Molecular weight: 174.15g/mol

Ref: 54-BUP14148

Dimethyl 2-ketoglutaconate

CAS: 13192-04-6

Molecular weight: 174.15

Ref: 7W-GM0289

Dimethyl α-ketoglutarate

CAS: 13192-04-6

Dimethyl α-ketoglutarate

Formula: C₇H₁₀O₅

Purity: 98%

Color and Shape: colourless liquid

Molecular weight: 174.15g/mol

Ref: 54-OR45005

Glutamic Acid Impurity 9 (Dimethyl 2-Ketoglutaconate)

CAS: 13192-04-6

Formula: C₇H₁₀O

Molecular weight: 174.15

Ref: 4Z-PG-3534

Dimethyl 2-ketoglutaconate

CAS: 13192-04-6

Dimethyl 2-ketoglutaconate (DMG) is an intermediate in the Krebs cycle and is a precursor for the production of glutamate, which is an important neurotransmitter. DMG has been shown to induce autophagy, a process by which cells clear out damaged proteins, organelles, and other cellular components. This process may be important in the treatment of various cancers such as cervical cancer or solid tumours. DMG has also been shown to inhibit hif-1α, a transcription factor that regulates many genes including those involved in tumor growth and metabolism. The effect of DMG on carcinoma cells can be enhanced with benzodiazepine binding. A study found that DMG was able to inhibit tumor growth in prostate cancer cells through metabolic changes that were not observed in normal cells. It also showed antiproliferative effects on human carcinoma cell lines induced by DMBA or benzo[a]pyrene treatments.

Formula: C₇H₁₀O₅

Purity: Min. 95%

Color and Shape: Clear Liquid

Molecular weight: 174.15 g/mol

Ref: 3D-FD22239

Dimethyl 2-oxopentanedioate

CAS: 13192-04-6

Formula: C₇H₁₀O₅

Purity: 95%

Color and Shape: Liquid

Molecular weight: 174.152

Ref: 10-F435702

TUN-92046

CAS: 13192-04-6

TUN-92046 is a permeable alpha-ketoglutarate analog that blocks harmful autophagy in cardiomyopathy.

Formula: C₇H₁₀O₅

Purity: 95.48% - 98.58%

Color and Shape: Solid

Molecular weight: 174.15

Ref: TM-T71961