CAS 131944-48-4

Tacrolimus Impurity 2

CAS: 131944-48-4

Formula: C₄₄H₆₉NO₁₂

Color and Shape: White To Off-White Solid

Molecular weight: 804.03

Ref: 4Z-T-399

(E/Z)-FK-506 26,28-Allylic Ester Rearrangement Impurity (>90%)

CAS: 131944-48-4

Formula: C₄₄H₆₉NO₁₂

Color and Shape: White To Light Yellow

Molecular weight: 804.02

Ref: TR-F370020

(E/Z)-FK-506 26,28-Allylic Ester Rearrangement Impurity

CAS: 131944-48-4

The impurity is a natural product and an API impurity. The impurity is synthesized by the rearrangement of (E/Z)-FK-506 26,28-allylic ester. This impurity has been shown to be present in drug products at concentrations up to 0.0025% w/w. It is found in analytical samples at concentrations up to 0.02% w/w, which may be due to its use as a HPLC standard. The impurity has been studied for metabolism in rats and rabbits and is not metabolized by microsomal enzymes or conjugated with glucuronic acid. The compound has also been shown to have anti-inflammatory properties in mice models and has no cardiotoxic effects on Balb/c mice.

Formula: C₄₄H₆₉NO₁₂

Purity: Min. 95%

Molecular weight: 804.02 g/mol

Ref: 3D-IF23294

Tacrolimus Impurity 14

CAS: 131944-48-4

Formula: C₄₄H₆₉NO₁₂

Molecular weight: 804.03

Ref: ST-EA-CP-T39034