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CAS 132-73-0

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Chloroquine sulfate

Description:
Chloroquine sulfate is an antimalarial medication primarily used to prevent and treat malaria, particularly that caused by Plasmodium vivax and Plasmodium falciparum. It is a synthetic derivative of quinine and belongs to the class of 4-aminoquinolines. The compound appears as a white to off-white crystalline powder and is soluble in water, making it suitable for oral administration. Chloroquine functions by interfering with the parasite's ability to metabolize hemoglobin, leading to the accumulation of toxic heme within the parasite. In addition to its antimalarial properties, chloroquine has been investigated for its potential use in treating autoimmune diseases such as rheumatoid arthritis and lupus erythematosus due to its immunomodulatory effects. However, its use has been associated with various side effects, including gastrointestinal disturbances, retinal toxicity, and potential cardiovascular issues. As with any medication, it is essential to use chloroquine sulfate under medical supervision to mitigate risks and ensure appropriate dosing.
Formula:C18H28ClN3O4S
InChI:InChI=1/C18H26ClN3.H2O4S/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);(H2,1,2,3,4)
InChI key:InChIKey=OJPWHUOVKVKBQB-UHFFFAOYSA-N
SMILES:S(=O)(=O)(O)O.N(C(CCCN(CC)CC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2
Synonyms:
  • 1,4-Pentanediamine, N(sub 4)-(7-chloro-4-quinolinyl)-N(sub 1),N(sub 1)-diethyl-, sulfate
  • 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, sulfate (1:1) (9CI)
  • 1,4-Pentanediamine, N<sup>4</sup>-(7-chloro-4-quinolinyl)-N<sup>1</sup>,N<sup>1</sup>-diethyl-, sulfate (1:1)
  • 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline sulfate (1:1)
  • 7-Chloro-4-(4′-diethylamino-1-methylbutylamino)quinoline sulfate
  • Chloroquin sulfate
  • Chloroquine sulphate
  • Chlorquine sulfate
  • Ciplaquin
  • Cisplaquin
  • See more synonyms
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