CAS 132-92-3

Methicillin sodium

Description:

Methicillin sodium is a semi-synthetic antibiotic belonging to the penicillin class, primarily used to treat infections caused by penicillinase-producing staphylococci. It is characterized by its ability to resist degradation by certain beta-lactamase enzymes, which makes it effective against specific bacterial strains. The compound appears as a white to off-white crystalline powder and is soluble in water, facilitating its administration via injection. Methicillin sodium is typically used in a clinical setting for serious infections, particularly those caused by Staphylococcus aureus. However, its use has declined due to the emergence of methicillin-resistant Staphylococcus aureus (MRSA) strains, which are resistant to this antibiotic. The pharmacokinetics of methicillin sodium involve rapid distribution in body tissues, with renal excretion being the primary route of elimination. While it is effective against certain bacteria, its spectrum of activity is limited compared to broader-spectrum antibiotics, necessitating careful consideration in treatment protocols. As with all antibiotics, appropriate use is crucial to minimize the development of resistance.

Formula: C₁₇H₂₀N₂O₆S·Na

InChI: InChI=1S/C17H20N2O6S.Na/c1-17(2)12(16(22)23)19-14(21)11(15(19)26-17)18-13(20)10-8(24-3)6-5-7-9(10)25-4;/h5-7,11-12,15H,1-4H3,(H,18,20)(H,22,23);/t11-,12+,15-;/m1./s1

InChI key: InChIKey=YPDBCTZTLGGIMN-UMLIZJHQSA-N

SMILES: C(O)(=O)[C@@H]1N2[C@@]([C@H](NC(=O)C3=C(OC)C=CC=C3OC)C2=O)(SC1(C)C)[H].[Na]

Synonyms:

• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-, monosodium salt
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-, monosodium salt, [2S-(2α,5α,6β)]-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-, sodium salt (1:1), (2S,5R,6R)-
• Azapen
• Belfacillin
• Brl 1241
• Celbenin
• Celpillina
• Celpilline
• Cinopenil
• Dimethoxyphenecillin sodium
• Dimocillin
• Dimocillin sodium
• Dimocillin-R-2
• Estafcilina
• Flabelline
• Lucopenin
• Methicillin Sodium
• Methicillin sodium salt
• Meticillin sodium salt
• Penaureus
• Penistaph
• Penysol
• Sodium (2,6-dimethoxyphenyl)penicillin
• Sodium 6-(2,6-Dimethoxybenzamido)Penicillanate
• Sodium 6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• Sodium 6-[(2,6-Dimethoxybenzoyl)Amino]-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate
• Sodium dimethoxyphenylpenicillin
• Sodium methicillin
• Sq 16123
• Staficyn
• Staphcillin
• Synticillin
• X-1497
• sodium (2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Methicillin sodium salt, 90+%

CAS: 132-92-3

Targets primarily the cell wall of Gram-positive organisms especially Staphylococcus aureus. Methicillin is used to study bacterium susceptibility, and to inhibit cell-wall synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional s

Formula: C₁₇H₁₉N₂NaO₆S

Purity: 90+%

Color and Shape: Powder, White to off-white

Molecular weight: 402.40

Ref: 02-J66414

Methicillin sodium salt

CAS: 132-92-3

Methicillin sodium salt is the sodium salt form of methicillin, a semisynthetic beta-lactam penicillin antibiotic with beta-lactamase resistant activity.

Formula: C₁₇H₁₉N₂NaO₆S

Purity: 78% - 93.36%

Color and Shape: Solid

Molecular weight: 402.40

Ref: TM-T0234

sodium 6-(2,6-dimethoxybenzamido)penicillanate

CAS: 132-92-3

Formula: C₁₇H₁₉N₂NaO₆S

Purity: 85%

Color and Shape: Solid

Molecular weight: 402.3973

Ref: IN-DA009CJ2

Methicillin sodium salt

CAS: 132-92-3

Methicillin sodium salt

Purity: ≥70%

Molecular weight: 402.4g/mol

Ref: 54-BUP16438

Methicillin Sodium

CAS: 132-92-3

Formula: C₁₇H₁₉N₂O₆SNa

Molecular weight: 379.41 22.99

Ref: 4Z-M-092001

Methicillin Sodium

Controlled Product

CAS: 132-92-3

Applications Semi-synthetic antibiotic related to Penicillin. Antimicrobial.
References Robinson, B., et al.: Biochem. Med. Metab. Biol., 48, 122 (1992), Lesnefsky, E., et al.: J. Biol. Chem., 279, 47961 (2004), Marroquin, L., et al.: Toxicol. Sci., 97, 539 (2007),

Formula: C₁₇H₁₉N₂O₆S·Na

Color and Shape: Neat

Molecular weight: 402.40

Ref: TR-M260175