CAS 132036-88-5

Ramosetron

Description:

Ramosetron is a selective serotonin 5-HT3 receptor antagonist primarily used in the management of nausea and vomiting, particularly in patients undergoing chemotherapy or surgery. It is characterized by its ability to block the action of serotonin at the 5-HT3 receptors, which are located in the central nervous system and gastrointestinal tract. This action helps to mitigate the emetic response triggered by various stimuli. Ramosetron is known for its relatively long half-life, allowing for less frequent dosing compared to some other antiemetics. The compound is typically administered orally or intravenously, depending on the clinical scenario. Its chemical structure includes a piperidine ring, contributing to its pharmacological properties. While generally well-tolerated, potential side effects may include headache, constipation, and dizziness. As with any medication, its use should be guided by a healthcare professional, considering individual patient factors and potential drug interactions.

Formula: C₁₇H₁₇N₃O

InChI: InChI=1S/C17H17N3O/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14/h2-5,9-11H,6-8H2,1H3,(H,18,19)/t11-/m1/s1

InChI key: InChIKey=NTHPAPBPFQJABD-LLVKDONJSA-N

SMILES: C(=O)(C=1C=2C(N(C)C1)=CC=CC2)[C@H]3CC4=C(CC3)N=CN4

Synonyms:

• (-)-(R)-1-Methylindol-3-yl 4,5,6,7-tetrahydro-5-benzimidazolylketone
• (1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]methanone
• (1-methyl-1H-indol-3-yl)[(6S)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]methanone
• (R)-5-[(1-Methylindole-3-Yl)Carbonyl]-4,5,6,7-Tetrahydro-1H-Bezimidazole, 98+%
• Methanone, (1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-, (R)-
• Methanone, (1-methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]-
• Methanone, (1-methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]- (9CI)
• Methanone, (1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]-
• Nasea
• Nor-YM 060
• Ramosetron

Methanone, (1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]-

CAS: 132036-88-5

Formula: C₁₇H₁₇N₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 279.3364

Ref: IN-DA001037

Ramosetron

CAS: 132036-88-5

Ramosetron 是一种血清素 5-HT3 受体拮抗剂，用于治疗恶心和呕吐。它被认为比其他一代 5-HT3 拮抗剂如昂丹司琼具有更高的效力和更长的止吐作用。它还适用于治疗“男性以腹泻为主的肠易激综合征”。它仅获准在日本和选定的东南亚国家使用。

Formula: C₁₇H₁₇N₃O

Purity: 98.84%

Color and Shape: Solid

Molecular weight: 279.34

Ref: TM-T4562