CAS 132172-14-6

(9E)-5,15,19-trihydroxy-3-[(E)-2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14-methoxy-4,10,12,18-tetramethyl-8-prop-2-en-1-yl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-16,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(

Description:

The chemical substance with the name "(9E)-5,15,19-trihydroxy-3-[(E)-2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14-methoxy-4,10,12,18-tetramethyl-8-prop-2-en-1-yl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-16,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21" and CAS number "132172-14-6" is a complex organic compound characterized by multiple hydroxyl groups, which suggest it may exhibit significant polarity and potential for hydrogen bonding. The presence of methoxy and propene functional groups indicates possible reactivity and versatility in chemical transformations. Its intricate structure, featuring a bicyclic framework and various methyl groups, implies a degree of steric hindrance, which could influence its biological activity and interaction with other molecules. This compound may be of interest in medicinal chemistry, particularly in the development of pharmaceuticals, due to its unique structural features that could confer specific biological properties. Further studies would be necessary to elucidate its full range of characteristics and potential applications.

Formula: C₄₃H₆₇NO₁₂

InChI: InChI=1/C43H67NO12/c1-9-12-30-18-24(2)17-25(3)19-36(54-8)38(48)37-21-27(5)43(52,56-37)40(49)41(50)44-16-11-10-13-31(44)42(51)55-39(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)53-7/h9,18,20,25,27-33,35-39,45-46,48,52H,1,10-17,19,21-23H2,2-8H3/b24-18+,26-20+

L 683519

CAS: 132172-14-6

L 683519 is one of the Tacrolimus impurities with immunosuppressant and could restrain the activity of FK-506 binding protein.

Formula: C₄₃H₆₇NO₁₂

Color and Shape: Solid

Molecular weight: 789.99

Ref: TM-T32462

Desmethyl tacrolimus

CAS: 132172-14-6

Tacrolimus is a macrolide antibiotic that binds to the calcineurin receptor and inhibits the production of cytokines. It is used to treat certain types of autoimmunity and hyperproliferation in patients with cancer, organ transplant recipients, and those who have undergone radiation therapy. The drug is available in two forms: tacrolimus (the natural form) and desmethyl tacrolimus (a metabolite). Desmethyl tacrolimus is produced by microbial transformation, which converts the natural form into a more water-soluble derivative. This conversion can be prevented by adding additives such as proton pump inhibitors or pde5 inhibitors. Symptoms of tacrolimus include hyperglycemia, hyperlipidemia, gastrointestinal disturbances, headache, fever, skin rash, diarrhea, and anemia. Tacrolimus has been shown to inhibit the activity of fk506-binding proteins in vitro and in vivo through competitive inhibition.

Formula: C₄₃H₆₇NO₁₂

Purity: Min. 90 Area-%

Color and Shape: White Powder

Molecular weight: 789.99 g/mol

Ref: 3D-ID158723

Desmethyl Tacrolimus

CAS: 132172-14-6

Formula: C₄₃H₆₇NO₁₂

Molecular weight: 790.00

Ref: ST-EA-CP-T39008

Desmethyl Tacrolimus

CAS: 132172-14-6

Formula: C₄₃H₆₇NO₁₂

Molecular weight: 790.01

Ref: 4Z-T-3919