CAS 132327-80-1: N(alpha)-fmoc-N(delta)-trityl-L-glutamine
Description:N(alpha)-Fmoc-N(delta)-trityl-L-glutamine is a protected derivative of the amino acid L-glutamine, commonly used in peptide synthesis and research. The "Fmoc" (9-fluorenylmethoxycarbonyl) group serves as a protective group for the amino terminus, allowing for selective reactions at the carboxyl end or within the peptide chain without interference from the amine. The "trityl" group, which is a bulky aromatic protecting group, is attached to the side chain amine of the glutamine residue, providing stability and preventing unwanted reactions during synthesis. This compound is typically white to off-white in appearance and is soluble in organic solvents such as dichloromethane and dimethylformamide, but less soluble in water. Its stability under standard laboratory conditions makes it suitable for various synthetic applications. The use of such protected amino acids is crucial in the field of peptide chemistry, particularly in solid-phase peptide synthesis, where the sequential addition of amino acids is performed to construct peptides with specific sequences and functionalities.
Formula:C39H34N2O5
InChI:InChI=1S/C39H34N2O5/c42-36(41-39(27-14-4-1-5-15-27,28-16-6-2-7-17-28)29-18-8-3-9-19-29)25-24-35(37(43)44)40-38(45)46-26-34-32-22-12-10-20-30(32)31-21-11-13-23-33(31)34/h1-23,34-35H,24-26H2,(H,40,45)(H,41,42)(H,43,44)/t35-/m0/s1
InChI key:InChIKey=WDGICUODAOGOMO-DHUJRADRSA-N
SMILES:O=C(OCC1C=2C=CC=CC2C=3C=CC=CC31)NC(C(=O)O)CCC(=O)NC(C=4C=CC=CC4)(C=5C=CC=CC5)C=6C=CC=CC6
- Synonyms:
- (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-(tritylamino)pentanoic acid
- <span class="text-smallcaps">L</span>-Glutamine, N<sup>2</sup>-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-(triphenylmethyl)-
- D-Glutamine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-(triphenylmethyl)-
- Fmoc-<span class="text-smallcaps">L</span>-Gln(Trt)-OH
- Fmoc-Gln(Trt)-OH
- Fmoc-L-Gln(Trt)-OH
- Fmoc-L-Glutamine(Trityl)
- N-Fmoc-N'-trityl-L-glutamine
- N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-trityl-L-glutamine
- N<sup>2</sup>-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(triphenylmethyl)-<span class="text-smallcaps">L</span>-glutamine
- See more synonyms
- Nalpha-Fmoc-Ndelta-trityl-L-glutamine
- na-fmoc-N-delta-trityl-L-glutamine