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CAS 132388-69-3

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N(alpha)-boc-N(delta)-trityl-L-glutamine

Description:
N(alpha)-Boc-N(delta)-trityl-L-glutamine is a protected derivative of the amino acid L-glutamine, commonly used in peptide synthesis and research. The "Boc" (tert-butyloxycarbonyl) group serves as a protective group for the amino functionality, enhancing the stability and reactivity of the molecule during synthetic procedures. The "trityl" group, which is a bulky aromatic protecting group, is attached to the side chain amine, providing steric hindrance that prevents unwanted reactions. This compound is typically white to off-white in appearance and is soluble in organic solvents such as dichloromethane and dimethyl sulfoxide, but less soluble in water. Its structure allows for selective deprotection under mild conditions, facilitating the synthesis of peptides with specific sequences. N(alpha)-Boc-N(delta)-trityl-L-glutamine is valuable in the field of medicinal chemistry and biochemistry for the development of peptide-based therapeutics and for studying protein interactions. Proper handling and storage conditions are essential to maintain its stability and reactivity.
Formula:C29H32N2O5
InChI:InChI=1/C29H32N2O5/c1-28(2,3)36-27(35)22-16-10-11-17-23(22)29(20-12-6-4-7-13-20,21-14-8-5-9-15-21)31-24(26(33)34)18-19-25(30)32/h4-17,24,31H,18-19H2,1-3H3,(H2,30,32)(H,33,34)/t24-/m1/s1
SMILES:CC(C)(C)OC(=O)c1ccccc1C(c1ccccc1)(c1ccccc1)N[C@H](CCC(=N)O)C(=O)O
Synonyms:
  • Boc-Gln(Trt)-OH
  • Benzoic acid, 2-[[[(1R)-4-amino-1-carboxy-4-oxobutyl]amino]diphenylmethyl]-, 1-(1,1-dimethylethyl) ester
  • N-Boc-N'-trityl-L-glutamine
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