CAS 13239-97-9

2-Thiocytidine

Description:

2-Thiocytidine is a nucleoside analog characterized by the presence of a sulfur atom in place of the oxygen atom at the 2-position of the ribose sugar moiety, which is a defining feature of its structure. This modification can influence its biological activity and stability compared to natural nucleosides. The compound is typically classified as a pyrimidine nucleoside, and it consists of a cytosine base linked to a ribose sugar. 2-Thiocytidine has garnered interest in biochemical research due to its potential applications in antiviral and anticancer therapies, as it may interfere with nucleic acid synthesis. Its unique sulfur substitution can also affect hydrogen bonding and base pairing properties, making it a subject of study in the context of nucleic acid interactions. Additionally, the compound's solubility, reactivity, and stability under various conditions are important characteristics that influence its utility in laboratory and therapeutic settings. Overall, 2-Thiocytidine represents a significant area of interest in medicinal chemistry and molecular biology.

Formula: C₉H₁₃N₃O₄S

InChI: InChI=1S/C9H13N3O4S/c10-5-1-2-12(9(17)11-5)8-7(15)6(14)4(3-13)16-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,17)/t4-,6-,7-,8-/m1/s1

InChI key: InChIKey=RHFUOMFWUGWKKO-XVFCMESISA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=S)N=C(N)C=C2

Synonyms:

• 2(1H)-Pyrimidinethione, 4-amino-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 4-amino-1-beta-D-ribofuranosylpyrimidine-2(1H)-thione
• 4-amino-1-pentofuranosylpyrimidine-2(1H)-thione
• Cytidine, 2-thio-
• 2(1H)-Pyrimidinethione, 4-amino-1-β-D-ribofuranosyl-
• 2-Thiocytidine

Cytidine, 2-thio-

CAS: 13239-97-9

Formula: C₉H₁₃N₃O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 259.2822

Ref: IN-DA0010MW

2-Thiocytidine

CAS: 13239-97-9

Ref: 7W-GN5717

2-Thiocytidine

CAS: 13239-97-9

2-Thiocytidine

Purity: ≥98%

Molecular weight: 259.28g/mol

Ref: 54-BUP09393

2-Thiocytidine

CAS: 13239-97-9

2-Thiocytidine is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and has a broad spectrum of antitumor activity.2-

Formula: C₉H₁₃N₃O₄S

Purity: 98.59%

Color and Shape: Solid

Molecular weight: 259.28

Ref: TM-TNU0436

2-Thiocytidine

Controlled Product

CAS: 13239-97-9

Stability Hygroscopic
Applications 2-Thiocytidine (CAS# 13239-97-9) is a cytidine analogue. A profiled metabolite in HFD-induced obese mice after oral administration of Huangjinya green tea extract.
References Li, M., et al.: Food and Chemical Toxicology, 145, 111744 (2020)

Formula: C₉H₁₃N₃O₄S

Color and Shape: Off White To Dark Brown

Molecular weight: 259.28

Ref: TR-T344418

2-Thiocytidine

CAS: 13239-97-9

2-Thiocytidine is a nucleoside that is an intermediate in the synthesis of thiamine. It has been shown to be effective in the treatment of prostate cancer cells, which may be due to its ability to inhibit protein synthesis. 2-Thiocytidine binds to the catalytic site of ribonucleotide reductase (RR) and inhibits the enzyme's activity, thereby inhibiting DNA synthesis. This drug also has been shown to inhibit crosslinking caused by UV light or other agents that generate reactive oxygen species. 2-Thiocytidine binds to the active site of RR and prevents the formation of the enzyme-substrate complex. This binding prevents reduction of ribose into ribonucleotides and inhibits DNA synthesis.

Formula: C₉H₁₃N₃O₄S

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 259.28 g/mol

Ref: 3D-NT02911

4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2(1H)-thione

CAS: 13239-97-9

Purity: 98%

Molecular weight: 259.2799988

Ref: 10-F758862