CAS 132418-35-0

Setipafant

Description:

Setipafant, with the CAS number 132418-35-0, is a chemical compound that has been studied primarily for its potential therapeutic applications, particularly in the context of inflammatory diseases and conditions related to the immune system. It functions as an antagonist of the platelet-activating factor (PAF) receptor, which plays a crucial role in various biological processes, including inflammation, allergic responses, and cardiovascular functions. Setipafant's mechanism of action involves blocking the effects of PAF, thereby modulating inflammatory responses. The compound has been investigated in clinical settings for its efficacy in treating conditions such as asthma and other respiratory disorders. In terms of its physical and chemical properties, Setipafant is characterized by its specific molecular structure, which contributes to its biological activity. As with many pharmacological agents, its safety profile, dosage, and potential side effects are critical considerations in its development and application in medical treatments.

Formula: C₂₆H₂₃ClN₆O₂S

InChI: InChI=1S/C26H23ClN6O2S/c1-15-30-31-22-13-28-24(18-5-3-4-6-20(18)27)23-19-11-12-32(14-21(19)36-25(23)33(15)22)26(34)29-16-7-9-17(35-2)10-8-16/h3-10H,11-14H2,1-2H3,(H,29,34)

InChI key: InChIKey=DDJKTQDAEYPACV-UHFFFAOYSA-N

SMILES: CC=1N2C3=C(C4=C(S3)CN(C(NC5=CC=C(OC)C=C5)=O)CC4)C(=NCC2=NN1)C6=C(Cl)C=CC=C6

Synonyms:

• 6-(2-Chlorophenyl)-7,10-dihydro-N-(4-methoxyphenyl)-1-methyl-4H-pyrido[4′,3′:4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-9(8H)-carboxamide
• 4H-Pyrido[4′,3′:4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-9(8H)-carboxamide, 6-(2-chlorophenyl)-7,10-dihydro-N-(4-methoxyphenyl)-1-methyl-
• Setipafant
• BN 50727

Setipafant

Controlled Product

CAS: 132418-35-0

Setipafant is a prodrug that is reconstituted with solvents to form a diluent that can be used in the manufacture of medicines. It is a hydrophobic compound and can be used as a linker for drugs that are insoluble in water. Setipafant has been shown to lower blood pressure by reducing the peripheral vascular resistance and increasing cardiac output. This drug also inhibits nitric oxide release from vascular endothelial cells, which may contribute to its hypotensive effects. The anti-viral activity of setipafant has been demonstrated in vitro against HIV-1, HSV-2, influenza A virus and vesicular stomatitis virus (VSV).

Formula: C₂₆H₂₃ClN₆O₂S

Purity: Min. 95%

Molecular weight: 519 g/mol

Ref: 3D-HFA41835

Setipafant

CAS: 132418-35-0

Setipafant is an antagonist of the platelet-activating factor.

Formula: C₂₆H₂₃ClN₆O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 519.02

Ref: TM-T16874