CAS 132449-89-9

Lesopitron dihydrochloride

Description:

Lesopitron dihydrochloride is a chemical compound primarily recognized for its pharmacological properties, particularly as a selective serotonin reuptake inhibitor (SSRI). It is often studied in the context of its potential applications in treating mood disorders, including depression and anxiety. The compound features a dihydrochloride salt form, which enhances its solubility and stability in aqueous solutions, making it suitable for various pharmaceutical formulations. Lesopitron's mechanism of action involves the modulation of serotonin levels in the brain, contributing to its therapeutic effects. In terms of physical characteristics, it is typically presented as a white to off-white crystalline powder. Safety and handling precautions are essential, as with many chemical substances, due to potential side effects and interactions with other medications. Research continues to explore its efficacy and safety profile, alongside any potential side effects associated with its use. As with any pharmaceutical compound, it is crucial to consult relevant literature and regulatory guidelines for comprehensive information regarding its characteristics and applications.

Formula: C₁₅H₂₁ClN₆・2ClH

InChI: InChI=1/C15H21ClN6.2ClH/c16-14-12-19-22(13-14)7-2-1-6-20-8-10-21(11-9-20)15-17-4-3-5-18-15;;/h3-5,12-13H,1-2,6-11H2;2*1H

SMILES: C(CCn1cc(cn1)Cl)CN1CCN(CC1)c1ncccn1.Cl.Cl

2-(4-(4-(4-Chloro-1H-pyrazol-1-yl)butyl)piperazin-1-yl)pyrimidine dihydrochloride

CAS: 132449-89-9

2-(4-(4-(4-Chloro-1H-pyrazol-1-yl)butyl)piperazin-1-yl)pyrimidine dihydrochloride

Purity: 98%

Molecular weight: 393.75g/mol

Ref: 54-OR1073769

Lesopitron dihydrochloride

CAS: 132449-89-9

Lesopitron is a selective 5-HT1A receptor agonist with a high affinity for this receptor. It has been shown to have a maximal response at about 5 microM. Lesopitron has a diameter of 155.5 Å and an aromatic hydrocarbon core with two hydrated electron-donating groups on the side chains. It is also an analog of metformin, which is known to be used in the treatment of type 2 diabetes and metabolic syndrome. Lesopitron has been shown to bind to both 5-HT2A and 5-HT1A receptors in Swiss Webster mice, as well as other serotonin receptors in rat brain membranes. The effective dose of lesopitron is unknown, but it is thought to be between 10 and 100 mg/kg body weight due to its high affinity for the 5-ht1a receptor. Lesopitron does not inhibit ATP sensitive K+ channels, which makes it safe for use in humans as well

Formula: C₁₅H₂₃Cl₃N₆

Purity: Min. 95%

Molecular weight: 393.7 g/mol

Ref: 3D-HFA44989

Lesopitron dihydrochloride

CAS: 132449-89-9

Lesopitron dihydrochloride with IC50 of 125 nM in rat hippocampal membranes, is a full and selective 5-HT1A receptor agonist.

Formula: C₁₅H₂₃Cl₃N₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 393.74

Ref: TM-T11839