CAS 13250-97-0

nor-Nalidixic acid

Description:

Nor-Nalidixic acid is a synthetic compound that belongs to the class of quinolone antibiotics. It is primarily characterized by its bicyclic structure, which includes a pyridine and a carboxylic acid functional group. This compound is known for its antibacterial properties, particularly against Gram-negative bacteria, and is often used in the treatment of urinary tract infections. Nor-Nalidixic acid exhibits moderate solubility in water and is typically administered in oral form. Its mechanism of action involves the inhibition of bacterial DNA gyrase, an enzyme critical for DNA replication and transcription. The compound is a derivative of nalidixic acid, with modifications that enhance its pharmacological profile. While it has been effective in clinical settings, its use has declined due to the emergence of bacterial resistance and the availability of newer antibiotics with broader spectra of activity. Safety and efficacy profiles are important considerations in its application, and it may have side effects typical of quinolone antibiotics, including gastrointestinal disturbances and potential effects on the central nervous system.

Formula: C₁₀H₈N₂O₃

InChI: InChI=1S/C10H8N2O3/c1-5-2-3-6-8(13)7(10(14)15)4-11-9(6)12-5/h2-4H,1H3,(H,14,15)(H,11,12,13)

InChI key: InChIKey=WHJTTWIMQIGVJK-UHFFFAOYSA-N

SMILES: OC=1C2=C(N=CC1C(O)=O)N=C(C)C=C2

Synonyms:

• 1,8-Naphthyridine-3-carboxylic acid, 4-hydroxy-7-methyl-
• 2-Methyl-5-hydroxy-1,8-naphthyridine-6-carboxylic acid
• 7-Methyl-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid
• NSC 117329
• nor-Nalidixic acid
• 4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid

1,8-Naphthyridine-3-carboxylic acid, 4-hydroxy-7-methyl-

CAS: 13250-97-0

Formula: C₁₀H₈N₂O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 204.1821

Ref: IN-DA0010RE

4-Hydroxy-7-Methyl-1,8-Naphthyridine-3-Carboxylic Acid

CAS: 13250-97-0

4-Hydroxy-7-Methyl-1,8-Naphthyridine-3-Carboxylic Acid

Purity: 97%

Molecular weight: 204.18g/mol

Ref: 54-OR1027607

7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

CAS: 13250-97-0

Purity: 97%(HPLC);RG

Molecular weight: 204.1849976

Ref: 10-F662870

4-Hydroxy-7-methyl-[1,8]naphthyridine-3-carboxylic acid

CAS: 13250-97-0

4-Hydroxy-7-methyl-[1,8]naphthyridine-3-carboxylic acid is a compound that has been shown to be an antibacterial agent. It has been shown to selectively inhibit the growth of Gram-positive bacteria by binding to the bacterial cell wall. 4-Hydroxy-7-methyl-[1,8]naphthyridine-3-carboxylic acid binds to amino acids in the peptidoglycan layer of the bacterial cell wall and inhibits the crosslinking of these amino acids with divalent ions such as calcium and magnesium. This leads to changes in solvation structures and decreases in hydrogen bonding interactions, which reduces the stability of the peptidoglycan layer. The spectrum for this molecule is anharmonic, which means that it does not have a harmonic frequency but instead has many frequencies that are related by integer numbers. The molecule can exist in three different forms: two tautomers (keto form

Formula: C₁₀H₈N₂O₃

Purity: Min. 95%

Molecular weight: 204.18 g/mol

Ref: 3D-NAA25097