CAS 132579-32-9

Rocepafant

Description:

Rocepafant, with the CAS number 132579-32-9, is a chemical compound that functions primarily as a selective antagonist of the chemokine receptor CCR1. This receptor is involved in various inflammatory processes and immune responses, making Rocepafant of interest in the context of treating conditions associated with excessive inflammation, such as autoimmune diseases and certain types of cancer. The compound has been studied for its potential therapeutic applications, particularly in modulating immune responses. In terms of its chemical characteristics, Rocepafant is typically characterized by its specific molecular structure, which includes functional groups that facilitate its interaction with the CCR1 receptor. Its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are also crucial for understanding its efficacy and safety profile in clinical settings. Overall, Rocepafant represents a significant area of research in the development of targeted therapies aimed at regulating immune system activity.

Formula: C₂₆H₂₃ClN₆OS₂

InChI: InChI=1S/C26H23ClN6OS2/c1-15-30-31-22-13-28-24(18-5-3-4-6-20(18)27)23-19-11-12-32(14-21(19)36-25(23)33(15)22)26(35)29-16-7-9-17(34-2)10-8-16/h3-10H,11-14H2,1-2H3,(H,29,35)

InChI key: InChIKey=WBGAFGNZNGJVNW-UHFFFAOYSA-N

SMILES: CC=1N2C3=C(C4=C(S3)CN(C(NC5=CC=C(OC)C=C5)=S)CC4)C(=NCC2=NN1)C6=C(Cl)C=CC=C6

Synonyms:

• BN 50730
• 6-(2-Chlorophenyl)-7,10-dihydro-N-(4-methoxyphenyl)-1-methyl-4H-pyrido[4′,3′:4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-9(8H)-carbothioamide
• 4H-Pyrido[4′,3′:4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-9(8H)-carbothioamide, 6-(2-chlorophenyl)-7,10-dihydro-N-(4-methoxyphenyl)-1-methyl-
• Rocepafant
• 6-(o-Chlorophenyl)-7,10-dihydro-1-methylthio-4H-pyrido[4′,3′:4,5]thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepine-9(8H)-carboxy-p-anisidide

Rocepafant

CAS: 132579-32-9

Rocepafant

Purity: ≥98%

Molecular weight: 535.08g/mol

Ref: 54-BUP11562

Rocepafant

CAS: 132579-32-9

Rocepafant (LAU8080), a PAF antagonist, reduces neonatal rat brain damage and inhibits TNF-α toxicity in L929 cells.

Formula: C₂₆H₂₃ClN₆OS₂

Purity: 97.31% - 98.95%

Color and Shape: Solid

Molecular weight: 535.08

Ref: TM-T28607