CAS 132682-98-5

Glufosfamide

Description:

Glufosfamide is a synthetic compound primarily used in the field of medicinal chemistry, particularly as an antitumor agent. It is a derivative of the alkylating agent ifosfamide, designed to enhance its therapeutic efficacy while potentially reducing toxicity. The chemical structure of glufosfamide includes a chloroethyl side chain, which is crucial for its mechanism of action, allowing it to form DNA cross-links and inhibit cancer cell proliferation. This compound is characterized by its solubility in water and organic solvents, which facilitates its formulation for clinical use. Glufosfamide has been investigated for its effectiveness against various types of cancers, including solid tumors, and is often studied in combination with other chemotherapeutic agents to improve treatment outcomes. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are essential for understanding its therapeutic window and potential side effects. As with many chemotherapeutic agents, careful monitoring of patients is necessary to manage adverse effects and optimize treatment regimens.

Formula: C₁₀H₂₁Cl₂N₂O₇P

InChI: InChI=1S/C10H21Cl2N2O7P/c11-1-3-13-22(19,14-4-2-12)21-10-9(18)8(17)7(16)6(5-15)20-10/h6-10,15-18H,1-5H2,(H2,13,14,19)/t6-,7-,8+,9-,10+/m1/s1

InChI key: InChIKey=PSVUJBVBCOISSP-SPFKKGSWSA-N

SMILES: O(P(NCCCl)(NCCCl)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

Synonyms:

• (2S,3R,4S,5S,6R)-2-Bis(2-chloroethylamino)phosphoryloxy-6-(hydroxymethyl)oxane-3,4,5-triol
• 1-O-{bis[(2-chloroethyl)amino]phosphoryl}-beta-D-glucopyranose
• D 19575
• Glucosylifosfamide mustard
• Glufosfamide,B-D-Glucopyranose, 1-(N,N'-Bis(2-Chloroethyl)Phosphorodiamidate)-
• β-<span class="text-smallcaps">D</span>-Glucopyranose, 1-[N,N′-bis(2-chloroethyl)phosphorodiamidate]
• Glufosfamide
• β-D-Glucopyranose, 1-[N,N′-bis(2-chloroethyl)phosphorodiamidate]

β-D-Glucopyranose, 1-[N,N'-bis(2-chloroethyl)phosphorodiamidate]

CAS: 132682-98-5

Formula: C₁₀H₂₁Cl₂N₂O₇P

Purity: 96%

Molecular weight: 383.1627

Ref: IN-DA0010ZP

Glufosfamide

CAS: 132682-98-5

Glufosfamide

Purity: ≥98%

Molecular weight: 383.16g/mol

Ref: 54-BUP01378

Glufosfamide

Controlled Product

CAS: 132682-98-5

Applications Glufosfamide is an alkylating cytotoxic agent with increased antitumor selectivity and active transmembrane transport mechanism, that belongs to the oxazaphosphorine class. It is an attractive new agent for cancer therapy in humans.
References Pohl, J., et al.: Cancer Chemother. Pharmacol., 35, 364 (1995); Mazur, L., et al.: Anticancer Drugs, 22, 488 (2011);

Formula: C₁₀H₂₁Cl₂N₂O₇P

Color and Shape: Neat

Molecular weight: 383.163

Ref: TR-G596880

Glufosfamide

CAS: 132682-98-5

Glufosfamide is a cytotoxic drug that is used in the treatment of some types of cancer. It is a prodrug that requires conversion to its active form, glufosfamid, by esterase enzymes before it can exert its genotoxic effects. Glufosfamide has shown to be active against platinum-resistant ovarian cancer and solid tumours. This drug also has been shown to inhibit the growth of prostate cancer cells and miapaca-2 cells, which are derived from pancreatic cancer. Glufosfamide has been found to have low toxicity in mice, but there may be adverse reactions when combined with other drugs such as erythromycin or ketoconazole.

Formula: C₁₀H₂₁Cl₂N₂O₇P

Purity: Min. 95%

Molecular weight: 383.16 g/mol

Ref: 3D-MG38563

Glufosfamide

CAS: 132682-98-5

Glufosfamide is a novel oxazolophosphamide compound with anticancer activity for the study of advanced non-small cell lung cancer.

Formula: C₁₀H₂₁Cl₂N₂O₇P

Purity: 99.72%

Color and Shape: Solid

Molecular weight: 383.16

Ref: TM-T15390