CAS 132684-59-4

fmoc-L-homophenylalanine

Description:

Fmoc-L-homophenylalanine is a derivative of the amino acid homophenylalanine, characterized by the presence of a 9-fluorenylmethoxycarbonyl (Fmoc) protective group. This compound is commonly used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS), due to its ability to protect the amino group while allowing for the coupling of other amino acids. The Fmoc group is stable under basic conditions and can be removed under mild acidic conditions, facilitating the sequential addition of amino acids. Fmoc-L-homophenylalanine features a side chain that includes a phenyl group, which contributes to its hydrophobic characteristics, making it useful in the design of peptides with specific structural and functional properties. The compound is typically white to off-white in appearance and is soluble in organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). Its applications extend beyond peptide synthesis to include studies in drug design and molecular biology, where it can influence the folding and stability of peptide structures.

Formula: C₂₅H₂₃NO₄

InChI: InChI=1/C25H23NO4/c27-24(28)23(15-14-17-8-2-1-3-9-17)26-25(29)30-16-22-20-12-6-4-10-18(20)19-11-5-7-13-21(19)22/h1-13,22-23H,14-16H2,(H,26,29)(H,27,28)/t23-/m1/s1

SMILES: c1ccc(cc1)CC[C@H](C(=O)O)N=C(O)OCC1c2ccccc2c2ccccc12

Synonyms:

• Fmoc-L-Beta-homo-Phe
• Fmoc-HoPhe-OH
• Fmoc-Hphe

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-homophenylalanine

CAS: 132684-59-4

Formula: C₂₅H₂₃NO₄

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 401.46

Ref: 3B-F1025

N-Fmoc-L-homophenylalanine, 95%

CAS: 132684-59-4

It is used as an active pharmaceutical intermediate. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not ch

Formula: C₂₅H₂₃NO₄

Purity: 95%

Color and Shape: White to pale cream, Powder

Molecular weight: 401.46

Ref: 02-H51973

Fmoc-Homophe-OH

CAS: 132684-59-4

NPC 14686 shows anti-inflammatory activity. The Fmoc amino acid blocks neutrophil recruitment via inhibition of leukocyte adhesion to endothelial cells.

Formula: C₂₅H₂₃NO₄

Purity: 99.9%

Color and Shape: White

Molecular weight: 401.46

Ref: 01-4011602

Benzenebutanoic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (αS)-

CAS: 132684-59-4

Formula: C₂₅H₂₃NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 401.4544

Ref: IN-DA0010ZL

Fmoc-Homophe-OH

CAS: 132684-59-4

Formula: C₂₅H₂₃NO₄

Molecular weight: 401.46

Ref: 7W-GM5762

L-Homophenylalanine, N-FMOC protected

CAS: 132684-59-4

L-Homophenylalanine, N-FMOC protected

Purity: 98%

Molecular weight: 401.45g/mol

Ref: 54-OR14562

Fmoc-L-homophenylalanine

CAS: 132684-59-4

Fmoc-L-homophenylalanine is a homophenylalanine analogue that inhibits the intracellular Ca2+ levels by binding to the ester linkages in the phospholipid membrane. This inhibits viral replication and has been shown to inhibit the replication of coronaviruses, such as SARS-CoV, and respiratory syncytial virus (RSV). Fmoc-L-homophenylalanine also inhibits lung fibroblasts from producing cytokines and chemokines, which may be due to its ability to inhibit methyl ketones, an important precursor for proinflammatory compounds. It also inhibits P. aeruginosa growth by preventing bacterial cells from synthesizing proteins and DNA.

Formula: C₂₅H₂₃NO₄

Purity: 90%

Color and Shape: Powder

Molecular weight: 401.45 g/mol

Ref: 3D-FF47415

Fmoc-l-Homophenylalanine

CAS: 132684-59-4

Formula: C₂₅H₂₃NO₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 401.462

Ref: 10-F046654