CAS 132705-51-2

Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate

Description:

Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate, often referred to as PyBrom, is a chemical compound characterized by its unique structure and properties. It features a phosphonium cation with three pyrrolidine rings and a bromine atom, paired with the hexafluorophosphate anion. This compound is typically used as a reagent in organic synthesis, particularly in the formation of carbon-carbon bonds and in various coupling reactions. Its high reactivity is attributed to the presence of the phosphonium group, which can facilitate nucleophilic substitutions. The hexafluorophosphate anion contributes to the compound's stability and solubility in polar solvents, making it suitable for a range of applications in synthetic chemistry. Additionally, PyBrom is known for its ability to act as a source of bromine in reactions, providing a versatile tool for chemists. Safety precautions should be observed when handling this compound, as it may pose hazards typical of organophosphorus compounds. Overall, Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate is a valuable reagent in modern organic synthesis.

Formula: C₁₂H₂₄BrF₆N₃P₂

InChI: InChI=1/C12H24BrN3P.F6P/c13-17(14-7-1-2-8-14,15-9-3-4-10-15)16-11-5-6-12-16;1-7(2,3,4,5)6/h1-12H2;/q+1;-1

Synonyms:

• PyBroP
• Bromo-tris-pyrrolidinophosphoniumhexafluorophosphate
• Bromo(Tripyrrolidin-1-Yl)Phosphonium Hexafluorophosphate
• BROMO-TRIS-PYRROLIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE
• Pyrrolidine phosphorus complex
• PYBROP(TM)
• Bromo-tris-pyrrolidino-phosphonium hexafluorophosphat
• Bromotri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 97%
• BROMO-TRIS-PYRROLIDINO-PHOSPHONIUM HEXFLUOROPHOSPHATE
• Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate ,97%
• PyBroP\(rg
• BROMOTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE
• Bromotri(pyrrolidin-1-yl)phosphoniumhexafluorophosphate
• PYBROP(R)

Bromotripyrrolidinophosphonium Hexafluorophosphate

CAS: 132705-51-2

Formula: C₁₂H₂₄BrF₆N₃P₂

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 466.19

Ref: 3B-B2680

Phosphorus(1+), bromotri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1)

CAS: 132705-51-2

Formula: C₁₂H₂₄BrF₆N₃P₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 466.1810

Ref: IN-DA00110Q

Bromo[tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate

CAS: 132705-51-2

Bromo[tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate

Formula: C₁₂H₂₄BrN₃P·PF₆

Purity: 98%

Color and Shape: off-white crystalline powder

Molecular weight: 466.18g/mol

Ref: 54-PC8353

PyBroP

CAS: 132705-51-2

PyBroP is a phosphonium salt used in peptide coupling chemistry, analogous to PyCloP. PyBroP shows high efficiency in the coupling of N-methylated amino acids and α,α-disubstituted amino acids, with excellent yields, no epimerisation and fast reaction rates. PyBroP is a stable solid which can be used in a one-pot procedure and is soluble in the solvents commonly used for peptide coupling chemistry. PyBroP is a derivative of the phosphonium coupling reagent BOP but contains a pyrrolidine moiety in place of the dimethylamine of BOP. The aim behind the design of PyBroP was to prevent the formation of the extremely toxic and carcinogenic by-product HMPA generated with BOP, but with comparable performances.

Formula: C₁₂H₂₄BrF₆N₃P₂

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 466.18 g/mol

Ref: 3D-FB15669

Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate

CAS: 132705-51-2

Formula: C₁₂H₂₄BrF₆N₃P₂

Purity: 97%

Color and Shape: Solid, Powder or Crystalline Powder

Molecular weight: 466.187

Ref: 10-F024897

Bromotripyrrolidinophosphonium Hexafluorophosphate

Controlled Product

CAS: 132705-51-2

Stability Moisture Sensitive
Applications Bromotripyrrolidinophosphonium Hexafluorophosphate is a peptide coupling reagent that has been used in the synthesis of rostate tumor specific peptide-peptoid hybrid prodrugs.
References Li, S., et. al.: Chem. Commun., 47, 12840 (2011); Lee, J., et. al.: Bioorg. Med. Chem. Lett., 25, 2849 (2015)

Formula: C₁₂H₂₄BrF₆N₃P₂

Color and Shape: Neat

Molecular weight: 466.18

Ref: TR-B687965

Bromotri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 97%

CAS: 132705-51-2

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₂H₂₄BrF₆N₃P₂

Purity: 97%

Color and Shape: White, Crystals or powder or crystalline powder

Molecular weight: 466.19

Ref: 02-L19384