CAS 132866-11-6: Lercanidipine hydrochloride
Description:Lercanidipine hydrochloride is a calcium channel blocker primarily used in the treatment of hypertension. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced blood pressure. The substance is characterized by its high lipophilicity, which enhances its absorption and bioavailability. Lercanidipine exhibits a long half-life, allowing for once-daily dosing, which improves patient compliance. It is typically administered in its hydrochloride salt form, which enhances its solubility in aqueous solutions. The compound is known for its selectivity for peripheral blood vessels, minimizing effects on cardiac contractility and heart rate. Common side effects may include peripheral edema, headache, and flushing. As with other calcium channel blockers, caution is advised in patients with certain cardiovascular conditions. Overall, lercanidipine hydrochloride is an effective antihypertensive agent with a favorable pharmacokinetic profile.
Formula:C36H41N3O6·ClH
InChI:InChI=1S/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H
InChI key:InChIKey=WMFYOYKPJLRMJI-UHFFFAOYSA-N
SMILES:Cl.O=C(OC)C1=C(NC(=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC2)C=3C=CC=CC3)C1C=4C=CC=C(C4)N(=O)=O)C)C
- Synonyms:
- 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)Methylamino]-1,1-Dimethylethyl Methyl Ester Hydrochloride
- 1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Methyl Ester Hydrochloride
- 1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylicAcid2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimeth
- 1-[(3,3-Diphenylpropyl)(Methyl)Amino]-2-Methylpropan-2-Yl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate Hydrochloride (1:1)
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester, monohydrochloride
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, hydrochloride (1:1)
- Cardiovasc
- Carmen
- Corifeo
- Lercadip
- See more synonyms
- Lercan
- Lercanidipine Hcl
- LercanidipineHcl
- Lercanidipinehydrochloride(Forr&Donly)
- Lercapin
- Lercaridipin HCL
- Lercaton
- Lerkamen
- Lervasc
- Lerzam
- Lotensyl
- Rec 15/2375
- Renovia
- Vasodip
- Zandip
- Zanicor
- Lercanidipine hydrochloride
